Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular …

Neuroprotection for ischemic stroke refers to strategies, applied singly or in combination, that
antagonize the injurious biochemical and molecular events that eventuate in irreversible …

Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-
5′-diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor …

The cholinergic system has a crucial role to play in visual function. Although cholinergic
drugs have been a focus of attention as glaucoma medications for reducing eye pressure …

The phospholipase A 2 family includes secretory phospholipase A 2, cytosolic
phospholipase A 2, plasmalogen-selective phospholipase A 2, and calcium-independent …

Brain phosphatidylcholine (PC) levels are regulated by a balance between synthesis and
hydrolysis. Pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and …

Cytidine 5'-diphosphocholine, CDP-choline, or citicoline is an essential intermediate in the
biosynthetic pathway of structural phospholipids in cell membranes, particularly …

This review is based on the previous one published in 2006–Secades JJ, Lorenzo JL.
Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin …

Neural membrane phospholipids are hydrolyzed by a group of enzymes known as
phospholipases. This process results in the generation of second messengers such as …

This review is based on the previous one published in 2010–Secades JJ. Citicoline:
pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62 …