NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

JM Adrover, SAC McDowell, XY He, DF Quail… - Cancer Cell, 2023 - cell.com
Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Neutrophil phenotypes and functions in cancer: A consensus statement

DF Quail, B Amulic, M Aziz, BJ Barnes… - Journal of Experimental …, 2022 - rupress.org
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Neutrophils in cancer carcinogenesis and metastasis

S **ong, L Dong, L Cheng - Journal of hematology & oncology, 2021 - Springer
In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

Neutrophils in cancer: heterogeneous and multifaceted

CC Hedrick, I Malanchi - Nature Reviews Immunology, 2022 - nature.com
Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Neutrophils in Cancer immunotherapy: friends or foes?

X Huang, E Nepovimova, V Adam, L Sivak, Z Heger… - Molecular cancer, 2024 - Springer
Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and
immunotherapy. As immune defense cells, neutrophils release toxic substances, including …

Dual effect of immune cells within tumour microenvironment: pro-and anti-tumour effects and their triggers

AC Peña-Romero, E Orenes-Piñero - Cancers, 2022 - mdpi.com
Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Tumor associated neutrophils. Their role in tumorigenesis, metastasis, prognosis and therapy

MT Masucci, M Minopoli, MV Carriero - Frontiers in oncology, 2019 - frontiersin.org
Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by
cytokines and chemokines, can be distinguished according to their activation and cytokine …

Neutrophils in physiology and pathology

A Aroca-Crevillén, T Vicanolo, S Ovadia… - Annual Review of …, 2024 - annualreviews.org
Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Engineering and targeting neutrophils for cancer therapy

J Zhang, J Gu, X Wang, C Ji, D Yu, M Wang… - Advanced …, 2024 - Wiley Online Library
Neutrophils are the most abundant white blood cells in the circulation and act as the first line
of defense against infections. Increasing evidence suggests that neutrophils possess …

Neutrophils in cancer: neutral no more

SB Coffelt, MD Wellenstein, KE de Visser - Nature Reviews Cancer, 2016 - nature.com
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound
healing. In the cancer setting, a newfound appreciation for neutrophils has come into view …