Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Quantitative phase imaging based on holography: trends and new perspectives

Z Huang, L Cao - Light: Science & Applications, 2024 - nature.com
Abstract In 1948, Dennis Gabor proposed the concept of holography, providing a pioneering
solution to a quantitative description of the optical wavefront. After 75 years of development …

Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA

KJ Kobayashi-Kirschvink, CS Comiter, S Gaddam… - Nature …, 2024 - nature.com
Single-cell RNA sequencing and other profiling assays have helped interrogate cells at
unprecedented resolution and scale, but are inherently destructive. Raman microscopy …

Quantitative phase imaging through an ultra-thin lensless fiber endoscope

J Sun, J Wu, S Wu, R Goswami, S Girardo… - Light: Science & …, 2022 - nature.com
Quantitative phase imaging (QPI) is a label-free technique providing both morphology and
quantitative biophysical information in biomedicine. However, applying such a powerful …

Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells

S Ghislanzoni, JW Kang, A Bresci, A Masella… - Biosensors, 2023 - mdpi.com
Wild-type p53 cancer therapy-induced senescent cells frequently engulf and degrade
neighboring ones inside a massive vacuole in their cytoplasm. After clearance of the …

High-speed live-cell interferometry: a new method for quantifying tumor drug resistance and heterogeneity

D Huang, KA Leslie, D Guest, O Yeshcheulova… - Analytical …, 2018 - ACS Publications
We report the development of high-speed live-cell interferometry (HSLCI), a new
multisample, multidrug testing platform for directly measuring tumor therapy response via …

Raman2RNA: Live-cell label-free prediction of single-cell RNA expression profiles by Raman microscopy

KJ Kobayashi-Kirschvink, S Gaddam… - bioRxiv, 2021 - biorxiv.org
Single cell RNA-Seq (scRNA-seq) and other profiling assays have opened new windows
into understanding the properties, regulation, dynamics, and function of cells at …

Investigating the Effect of Polypyrrole–Gelatin/Silk Fibroin Hydrogel Mediated Pulsed Electrical Stimulation for Skin Regeneration

G Kulkarni, P Guha Ray, KC Sunka, K Dixit… - … Applied Materials & …, 2024 - ACS Publications
In clinical practice to treat complex injuries, the application of electrical stimulation (ES)
directly to the skin complicates the wound. In this work, the effect of a conductive hydrogel …

[HTML][HTML] Focus: medical technology: combining three-dimensional quantitative phase imaging and fluorescence microscopy for the study of cell pathophysiology

YS Kim, SY Lee, JH Jung, S Shin, HG Choi… - The Yale Journal of …, 2018 - ncbi.nlm.nih.gov
Quantitative phase imaging (QPI) has emerged as one of the powerful imaging tools for the
study of live cells in a non-invasive manner. In particular, multimodal approaches combining …

Raman Spectroscopy in Cellular and Tissue Aging Research

JH Kim, D Yang, S Park - Aging Cell, 2025 - Wiley Online Library
The establishment of various molecular, physiological, and genetic markers for cellular
senescence and aging‐associated conditions has progressed the aging study. To identify …