The advantage of using immunoinformatic tools on vaccine design and development for coronavirus

J García-Machorro, GL Ramírez-Salinas… - Vaccines, 2022 - mdpi.com
After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies
became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants …

Universal peptide-based potential vaccine design against canine distemper virus (CDV) using a vaccinomic approach

S Rendon-Marin, J Ruíz-Saenz - Scientific Reports, 2024 - nature.com
Canine distemper virus (CDV) affects many domestic and wild animals. Variations among
CDV genome linages could lead to vaccination failure. To date, there are several vaccine …

Advances in computational and bioinformatics tools and databases for designing and develo** a multi-epitope-based peptide vaccine

MMAK Shawan, AR Sharma, SK Halder… - International journal of …, 2023 - Springer
A vaccine is defined as a biologic preparation that trains the immune system, boosts
immunity, and protects against a deadly microbial infection. They have been used for …

Whole Proteome-Based Therapeutic Targets Annotation and Designing of Multi-Epitope-Based Vaccines against the Gram-Negative XDR-Alcaligenes faecalis …

M Alharbi, A Alshammari, AF Alasmari, S Alharbi… - Vaccines, 2022 - mdpi.com
This study involved therapeutic targets mining for the extremely drug-resistant bacterial
species called Alcaligenes faecalis, which is known to infect humans. The infections caused …

Towards specie-specific ensemble vaccine candidates against mammarenaviruses using optimized structural vaccinology pipeline and molecular modelling …

T Khan, A Muzaffar, RM Shoaib, A Khan… - Microbial …, 2022 - Elsevier
Mammarena viruses are emerging pathogenic agents and cause hemorrhagic fevers in
humans. These viruses accomplish host immune system evasion to replicate and spread in …

Exploring and targeting potential druggable antimicrobial resistance targets ArgS, SecY, and MurA in Staphylococcus sciuri with TCM inhibitors through a subtractive …

A Khan, S Sohail, S Yaseen, S Fatima, A Wisal… - Functional & Integrative …, 2023 - Springer
Staphylococcus sciuri (also currently Mammaliicoccus sciuri) are anaerobic facultative and
non-motile bacteria that cause significant human pathogenesis such as endocarditis, wound …

In silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD

J Shi, Y Zhu, Z Yin, Y He, Y Li, G Haimiti, X **e… - Scientific Reports, 2024 - nature.com
Brucella, a gram-negative intracellular bacterium, causing Brucellosis, a zoonotic disease
with a range of clinical manifestations, from asymptomatic to fever, fatigue, loss of appetite …

Designing a multi-epitope subunit vaccine against Toxoplasma gondii through reverse vaccinology approach

N Ahmed, NA Rani, TB Robin, MN Mashrur… - Molecular and …, 2024 - Elsevier
The parasite Toxoplasma gondii, or T. gondii, is zoonotic that both individuals as well as
animals can contract resulting in toxoplasmosis, a life-threatening illness. We used an …

Exploring the impact of taurine on the biochemical properties of urate oxidase: response surface methodology and molecular dynamics simulation

P Shahmoradipour, M Zaboli… - Journal of Biological …, 2024 - Springer
This paper investigates the impact of taurine as an additive on the structural and functional
stability of urate oxidase. First, the effect of the processing parameters for the stabilization of …

Development of innovative multi-epitope mRNA vaccine against central nervous system tuberculosis using in silico approaches

H Shi, Y Zhu, K Shang, T Tian, Z Yin, J Shi, Y He… - Plos one, 2024 - journals.plos.org
Tuberculosis (TB) of the Central nervous system (CNS) is a rare and highly destructive
disease. The emergence of drug resistance has increased treatment difficulty, leaving the …