Fiber-type shifting in sarcopenia of old age: proteomic profiling of the contractile apparatus of skeletal muscles

P Dowling, S Gargan, D Swandulla… - International Journal of …, 2023 - mdpi.com
The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

The effects of acute and chronic exercise on skeletal muscle proteome

BA Petriz, CPC Gomes, JA Almeida… - Journal of cellular …, 2017 - Wiley Online Library
Skeletal muscle plasticity and its adaptation to exercise is a topic that is widely discussed
and investigated due to its primary role in the field of exercise performance and health …

The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

BA Hodge, Y Wen, LA Riley, X Zhang, JH England… - Skeletal muscle, 2015 - Springer
Background Skeletal muscle is a major contributor to whole-body metabolism as it serves as
a depot for both glucose and amino acids, and is a highly metabolically active tissue. Within …

Influence of vitamin C and vitamin E on redox signaling: Implications for exercise adaptations

JN Cobley, H McHardy, JP Morton… - Free Radical Biology …, 2015 - Elsevier
The exogenous antioxidants vitamin C (ascorbate) and vitamin E (α-tocopherol) often blunt
favorable cell signaling responses to exercise, suggesting that redox signaling contributes to …

[HTML][HTML] Exercise redox biochemistry: conceptual, methodological and technical recommendations

JN Cobley, GL Close, DM Bailey, GW Davison - Redox biology, 2017 - Elsevier
Exercise redox biochemistry is of considerable interest owing to its translational value in
health and disease. However, unaddressed conceptual, methodological and technical …

Exploring the unmapped cysteine redox proteoform landscape

JN Cobley - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
Cysteine redox proteoforms define the diverse molecular states that proteins with cysteine
residues can adopt. A protein with one cysteine residue must adopt one of two binary …

[HTML][HTML] Ten “Cheat Codes” for Measuring Oxidative Stress in Humans

JN Cobley, NV Margaritelis, PN Chatzinikolaou… - Antioxidants, 2024 - mdpi.com
Formidable and often seemingly insurmountable conceptual, technical, and methodological
challenges hamper the measurement of oxidative stress in humans. For instance, fraught …

Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise

DM Camera, JG Burniston… - The FASEB …, 2017 - acuresearchbank.acu.edu.au
It is generally accepted that muscle adaptation to resistance exercise (REX) training is
underpinned by contraction-induced, increased rates of protein synthesis and dietary protein …

Principles for integrating reactive species into in vivo biological processes: examples from exercise physiology

NV Margaritelis, JN Cobley, V Paschalis, AS Veskoukis… - Cellular signalling, 2016 - Elsevier
The equivocal role of reactive species and redox signaling in exercise responses and
adaptations is an example clearly showing the inadequacy of current redox biology research …

Quantification of exercise‐regulated ubiquitin signaling in human skeletal muscle identifies protein modification cross talk via NEDDylation

BL Parker, B Kiens, JFP Wojtaszewski… - The FASEB …, 2020 - Wiley Online Library
The maintenance of muscle function is extremely important for whole body health and
exercise is essential to this process. The ubiquitin‐proteasome system (UPS) is required for …