Amino acid fermentation is one of the major pillars of industrial biotechnology. The multi-
billion USD amino acid market is rising steadily and is diversifying. Metabolic engineering is …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

To broaden the substrate scope of microbial cell factories towards renewable substrates,
rational genetic interventions are often combined with adaptive laboratory evolution (ALE) …

Carbon source is crucial for the cell growth and metabolism in microorganisms, and its
utilization significantly affects the synthesis efficiency of target products in microbial cell …

The emergency of antibiotic-resistant bacteria in severe infections is increasing, especially
in nosocomial environments. The ESKAPE group is of special importance in the groups of …

Adaptive laboratory evolution has proven a valuable strategy for metabolic engineering.
Here, we established an experimental evolution approach for improving microbial …

Synthetic biology aims to design and construct bacterial genomes harboring the minimum
number of genes required for self-replicable life. However, the genome-reduced bacteria …

Adaptive laboratory evolution (ALE) has emerged as a valuable method by which to
investigate microbial adaptation to a desired environment. Here, we performed ALE to 42° C …

Background Biofuel production from plant cell walls offers the potential for sustainable and
economically attractive alternatives to petroleum-based products. Fuels from cellulosic …

Organisms adjust their gene expression to improve fitness in diverse environments. But
finding the optimal expression in each environment presents a challenge. We ask how good …