BACKGROUND The human brain contains about 100 billion neurons, each of which makes
thousands of synaptic connections. Although individual neurons can themselves be …

Adult neurogenesis, a process of generating functional neurons from adult neural
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …

The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is …

The Cre/loxP system has been used extensively for conditional mutagenesis in mice.
Reporters of Cre activity are important for defining the spatial and temporal extent of Cre …

Human diseases are often caused by loss of somatic cells that are incapable of re-entering
the cell cycle for regenerative repair. Here, we report a combination of cell-cycle regulators …

Detailed analysis of neuronal network architecture requires the development of new
methods. Here we present strategies to visualize synaptic circuits by genetically labelling …

Astroglial scars surround damaged tissue after trauma, stroke, infection, or autoimmune
inflammation in the CNS. They are essential for wound repair, but also interfere with axonal …

Neurogenesis and gliogenesis continue in discrete regions of the adult mammalian brain. A
fundamental question remains whether cell genesis occurs from distinct lineage-restricted …

Animals constantly receive various sensory stimuli, such as odours, sounds, light and touch,
from the surrounding environment. These sensory inputs are essential for animals to search …

Lineage tracing is the identification of all progeny of a single cell. Although its origins date
back to developmental biology of invertebrates in the 19 th century, lineage tracing is now …