In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Metabolism reprogramming is critical for both cancer progression and effective immune
responses in the tumor microenvironment. Amino acid metabolism in different cells and their …

Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

Control of integrin affinity for ligands (integrin activation) is essential for normal cell
adhesion, migration, and assembly of an extracellular matrix. Integrin activation is usually …

A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel
Na+-independent neutral amino acid transporter designated LAT1. For functional …

Integrins are heterodimeric cell adhesion molecules that link the extracellular matrix to the
cytoskeleton. The integrin family in man comprises 24 members, which are the result of …

System L is a major nutrient transport system responsible for the transport of large neutral
amino acids including several essential amino acids. We previously identified a transporter …

Palacı́n, Manuel, Raúl Estévez, Joan Bertran, and Antonio Zorzano. Molecular Biology of
Mammalian Plasma Membrane Amino Acid Transporters. Physiol. Rev. 78: 969–1054, 1998 …

ADHESION IS REQUIRED for cell growth, differentiation, survival, and function. Nowhere is
this more evident than in the response to tissue injury, where vascular damage triggers …

Galectin-3 is a β-galactoside-binding protein implicated in diverse biological processes. We
found that galectin-3 induced human monocyte migration in vitro in a dose-dependent …