Cell-based strategies for IVD repair: clinical progress and translational obstacles
ALA Binch, JC Fitzgerald, EA Growney… - Nature Reviews …, 2021 - nature.com
Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …
chronic condition that has a striking effect on quality of life. Currently, no approved …
Materials for the spine: anatomy, problems, and solutions
Disc degeneration affects 12% to 35% of a given population, based on genetics, age,
gender, and other environmental factors, and usually occurs in the lumbar spine due to …
gender, and other environmental factors, and usually occurs in the lumbar spine due to …
Intervertebral disc degeneration—Current therapeutic options and challenges
Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …
declining function and the development of pain, it may affect one's physical health, mental …
Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations
TJ DiStefano, K Vaso, G Danias… - Advanced …, 2022 - Wiley Online Library
Emergent approaches in regenerative medicine look toward the use of extracellular vesicles
(EVs) as a next‐generation treatment strategy for intervertebral disc (IVD) degeneration …
(EVs) as a next‐generation treatment strategy for intervertebral disc (IVD) degeneration …
Interaction between mesenchymal stem cells and intervertebral disc microenvironment: from cell therapy to tissue engineering
Low back pain (LBP) in one of the most disabling symptoms affecting nearly 80% of the
population worldwide. Its primary cause seems to be intervertebral disc degeneration (IDD) …
population worldwide. Its primary cause seems to be intervertebral disc degeneration (IDD) …
[HTML][HTML] The role of structure and function changes of sensory nervous system in intervertebral disc-related low back pain
S Zhang, B Hu, W Liu, P Wang, X Lv, S Chen… - Osteoarthritis and …, 2021 - Elsevier
Low back pain (LBP) is a common musculoskeletal symptom, which can be developed in
multiple clinical diseases. It is widely recognized that intervertebral disc (IVD) degeneration …
multiple clinical diseases. It is widely recognized that intervertebral disc (IVD) degeneration …
Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
Imaging evaluation of intervertebral disc degeneration and painful discs—advances and challenges in quantitative MRI
In recent years, various quantitative and functional magnetic resonance imaging (MRI)
sequences have been developed and used in clinical practice for the diagnosis of patients …
sequences have been developed and used in clinical practice for the diagnosis of patients …
[HTML][HTML] Emerging tissue engineering strategies for annulus fibrosus therapy
A Zhang, Z Cheng, Y Chen, P Shi, W Gan, Y Zhang - Acta Biomaterialia, 2023 - Elsevier
Low back pain is a major public health concern experienced by 80% of the world's
population during their lifetime, which is closely associated with intervertebral disc (IVD) …
population during their lifetime, which is closely associated with intervertebral disc (IVD) …
New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs
T Lan, Z Shen, B Yan, J Chen - Ageing research reviews, 2021 - Elsevier
Intervertebral disc degeneration (IDD) has been widely known as a main contributor to low
back pain which has a negative socioeconomic impact worldwide. However, the underlying …
back pain which has a negative socioeconomic impact worldwide. However, the underlying …