The dynamics of biological processes depend on the structure and flexibility of the
interacting molecules. In particular, the conformational diversity of DNA allows for large …

The integration of viral cDNA into the host genome is an essential step in the HIV‐1‐life
cycle and is mediated by the virally encoded enzyme, integrase (IN). Inhibition of this …

Linker histones are essential for chromatin filament formation, and they play key roles in the
regulation of gene expression. Despite the determination of structures of the nucleosome …

Computational docking is a useful tool for predicting macromolecular complexes, which are
often difficult to determine experimentally. Here, we present the DOT2 software suite, an …

Essential to understanding life, the biomolecular phenomena have been an important
subject in science, therefore a necessary path to be covered to make progress in human …

Mononuclear silver (I) complexes with 1, 7-phenanthroline (1, 7-phen),[Ag (NO 3-O, O′)(1,
7-phen-N7) 2](1) and [Ag (1, 7-phen-N7) 2] X, X= ClO 4−(2), CF 3 SO 3−(3), BF 4−(4) and …

Abstract Background HIV-1 integrase (IN) is an emerging drug target, as IN strand transfer
inhibitors (INSTIs) are proving potent antiretroviral agents in clinical trials. One credible …

The catalytic core domain (CCD) of human immunodeficiency virus type 1 (HIV-1) integrase
(IN) harbors the enzyme active site and binds viral and chromosomal DNA during …

The synthesis, spectroscopic characterization, cytotoxic activity and DNA binding evaluation
of seven new dinuclear platinum (II) complexes Pt1–Pt7, with the general formula [{Pt (L) Cl} …

The intrinsic flexibility of DNA and the difficulty of identifying its interaction surface have long
been challenges that prevented the development of efficient protein–DNA docking methods …