➤ There are a number of potential clinical applications for growth factors in the enhancement
of bone repair, including acceleration of fracture-healing, treatment of established …

During osteogenesis, osteoblasts lay down osteoid and transform into osteocytes embedded
in mineralized bone matrix. Despite the fact that osteocytes are the most abundant cellular …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

We have recently demonstrated the formation of interconnecting canalicular cell processes
in bone cells upon contact with basement membrane components. Here we have …

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation,
migration, differentiation, and survival of many different cell types. It influences such diverse …

Strategies to reduce blood loss and transfusion of allogeneic blood products during surgical
procedures are important in modern times. The most important and well-known autologous …

Following the initial purification and characterization of transforming growth factor-p (TGF-p)
as a homodimeric, 25-kDa peptide (FROLIK et al. 1983; As-SOlAN et al. 1983; ROBERTS et …

In the 10 years since its definition and characterization, TGF-β has come to be accepted as
the prototypical multifunctional peptide growth factor. Attempts to understand its mechanism …

BONE differs from reproductive tissues in that many aspects of skeletal growth, turnover, and
function occur in the absence of gonadal hormones. Nevertheless, sex steroids have an …

I. Introduction P HYSICIANS have traditionally considered PTH to be an agent that is
catabolic to the skeleton. However, as early as 60 yr ago, Albright and his colleagues (1) …