Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA …
A PI3Kα-selective inhibitor has recently been approved for use in breast tumors harboring
mutations in PIK3CA, the gene encoding p110α. Preclinical studies have suggested that the …
mutations in PIK3CA, the gene encoding p110α. Preclinical studies have suggested that the …
Maximizing small biopsy patient samples: unified RNA-Seq platform assessment of over 120,000 patient biopsies
Despite its wide-ranging benefits, whole-transcriptome or RNA exome profiling is
challenging to implement in a clinical diagnostic setting. The Unified Assay is a …
challenging to implement in a clinical diagnostic setting. The Unified Assay is a …
Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer
S Tang, Q Wang, K Sun, Y Song, R Liu, X Tan, H Li… - Apoptosis, 2024 - Springer
Background Breast cancer (BC) exhibits remarkable heterogeneity. However, the
transcriptomic heterogeneity of BC at the single-cell level has not been fully elucidated …
transcriptomic heterogeneity of BC at the single-cell level has not been fully elucidated …
Allele imbalance in mRNA is selected in tumorigenesis, results from epigenetic alterations and has prognostic relevance
Allele-specific expression (ASE) is the differential abundance in levels of mRNAs that
originated from the paternal and maternal copies of a gene. Such allelic imbalances can …
originated from the paternal and maternal copies of a gene. Such allelic imbalances can …
Single-cell allelic transcriptomic analysis unravels intratumoral gene expression heterogeneity linked to TNBC pathogenesis
Triple-negative breast cancer (TNBC) is the most aggressive subclass of breast cancer,
which exhibits high intratumoral heterogeneity. Intratumoral heterogeneity often drives the …
which exhibits high intratumoral heterogeneity. Intratumoral heterogeneity often drives the …
Deciphering the Genetic Alterations in PIK3CA Gene Interacting Network and Their Putative Association with Breast Cancer: A Computational Approach
Background: Cancer is a polygenic complex disorder involving a network of genes. The
phosphatidylinositol 3-kinase (PIK3CA) has been reported as an oncogene that plays a role …
phosphatidylinositol 3-kinase (PIK3CA) has been reported as an oncogene that plays a role …
Rigorous software pipeline for clinical somatic mutation analyses of solid tumors
I Stoimenov, M Rashyna, T Adlerteg, L Nunes… - medRxiv, 2023 - medrxiv.org
Mutational analyses of tumor DNA guide the use of targeted therapies and checkpoint
inhibitors in management of solid tumors. Reducing false positive mutation calls without …
inhibitors in management of solid tumors. Reducing false positive mutation calls without …
[PDF][PDF] Allele-specific expression is selected in tumorigenesis, results from epigenetic changes and has prognostic relevance
G Palou-Márquez, P Pericot-Masdevall, F Supek - biorxiv.org
Allele-specific expression (ASE) is the differential abundance in levels of mRNAs that
originated from the paternal and maternal copies of a gene. Such allelic imbalances can …
originated from the paternal and maternal copies of a gene. Such allelic imbalances can …