Molecular mechanisms underlying cardiac adaptation to exercise

RB Vega, JP Konhilas, DP Kelly, LA Leinwand - Cell metabolism, 2017 - cell.com
Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

[PDF][PDF] Animal models in the study of exercise-induced cardiac hypertrophy

Y Wang, U Wisloff, OJ Kemi - Physiological research, 2010 - biomed.cas.cz
Exercise training-induced cardiac hypertrophy occurs following a program of aerobic
endurance exercise training and it is considered as a physiologically beneficial adaptation …

Interaction between exercise and hypertension in spontaneously hypertensive rats: a meta-analysis of experimental studies

KD Schlüter, R Schreckenberg… - Hypertension …, 2010 - nature.com
The effect of exercise on the progression of hypertension and development of heart failure
has been extensively studied in spontaneously hypertensive rats (SHRs), but results …

Cardiac adaptation to exercise training in health and disease

DY Seo, HB Kwak, AH Kim, SH Park, JW Heo… - … -European Journal of …, 2020 - Springer
The heart is the primary pump that circulates blood through the entire cardiovascular system,
serving many important functions in the body. Exercise training provides favorable …

Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart

AJ Chicco, CM Schneider… - American Journal of …, 2005 - journals.physiology.org
The clinical use of doxorubicin (DOX) is limited by a dose-dependent cardiotoxicity. The
purpose of this study was to determine whether voluntary exercise training would confer …

The benefits of endurance training in cardiomyocyte function in hypertensive rats are reversed within four weeks of detraining

MA Carneiro-Júnior, JF Quintão-Júnior… - Journal of Molecular and …, 2013 - Elsevier
The aim of the present study was to verify the effects of low-intensity endurance training and
detraining on the mechanical and molecular properties of cardiomyocytes from …

Resistance exercise training benefits pulmonary, cardiac, and muscular structure and function in rats with stable pulmonary artery hypertension

LL Soares, LB Leite, LOG Ervilha, BRA Pelozin… - Life Sciences, 2023 - Elsevier
Aim We tested the effects of low-to moderate-intensity resistance exercise training (RT) on
the structure and function of pulmonary, right ventricle (RV), and skeletal muscle tissues in …

Differential regulation of perineuronal nets in the brain and spinal cord with exercise training

CC Smith, R Mauricio, L Nobre, B Marsh, RCI Wüst… - Brain research …, 2015 - Elsevier
Perineuronal nets (PNNs) are lattice like structures which encapsulate the cell body and
proximal dendrites of many neurons and are thought to be involved in regulating synaptic …

Resistance training regulates cardiac function through modulation of miRNA-214

SFS Melo, VG Barauna, MAC Júnior, LHM Bozi… - International Journal of …, 2015 - mdpi.com
Aims: To determine the effects of resistance training (RT) on the expression of microRNA
(miRNA)-214 and its target in sarcoplasmic reticulum Ca2+-ATPase (SERCA2a), and on the …

An analysis of the global expression of microRNAs in an experimental model of physiological left ventricular hypertrophy

NC Martinelli, CR Cohen, KG Santos, MA Castro… - PloS one, 2014 - journals.plos.org
Background MicroRNAs (miRs) are a class of small non-coding RNAs that regulate gene
expression. Studies of transgenic mouse models have indicated that deregulation of a single …