Neonates have little immunological memory and a develo** immune system, which
increases their vulnerability to infectious agents. Recent advances in the understanding of …

The early stages of life are associated with increased susceptibility to infection, which is in
part due to an ineffective immune system. In the context of infection, the immune system …

Allergic disease originates in early life and polymorphisms in interleukin-33 gene (IL33) and
IL1RL1, coding for IL-33R and decoy receptor sST2, confer allergy risk. Early life T helper 2 …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a
new emphasis in research; interdisciplinary work suggests that personalized medicine is on …

The past decade has brought great strides in our understanding of adaptive immunity in
neonatal mice. Although poor immune responses are commonly observed, it is now clear …

Childhood adversity has been repeatedly and robustly linked to physical and mental illness
across the lifespan. Yet, the biological pathways through which this occurs remain unclear …

Tuberculosis continues to cause an unacceptably high toll of disease and death among
children worldwide, particularly in the wake of the HIV epidemic. Increased international …

It is well established that adaptive immune responses are deficient in early life, contributing
to increased mortality and morbidity. The developmental trajectories of different components …

The human neonate and infant are unduly susceptible to infection with a wide variety of
microbes. This susceptibility is thought to reflect differences from adults in innate and …