The semantics of microglia activation: neuroinflammation, homeostasis, and stress
Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …
every area of neuroscience. Initial reports focused on classical immune functions of …
The emerging tale of microglia in psychiatric disorders
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …
response and play an increasingly important role in maintaining homeostatic brain functions …
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
Microglial inflammatory-metabolic pathways and their potential therapeutic implication in major depressive disorder
Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …
Stress induced microglial activation contributes to depression
B Li, W Yang, T Ge, Y Wang, R Cui - Pharmacological research, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
[HTML][HTML] Neurovascular adaptations modulating cognition, mood, and stress responses
The neurovascular unit (NVU) is a dynamic center for substance exchange between the
blood and the brain, making it an essential gatekeeper for central nervous system (CNS) …
blood and the brain, making it an essential gatekeeper for central nervous system (CNS) …
Major depressive disorder: hypothesis, mechanism, prevention and treatment
L Cui, S Li, S Wang, X Wu, Y Liu, W Yu… - … and Targeted Therapy, 2024 - nature.com
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …
Lactobacillus paracasei CCFM1229 and Lactobacillus rhamnosus CCFM1228 Alleviated Depression- and Anxiety-Related Symptoms of Chronic Stress-Induced …
Depression is a common mood disorder that affects around 350 million people worldwide.
We studied the effect of supplementation with Lactobacillus strains for the treatment of …
We studied the effect of supplementation with Lactobacillus strains for the treatment of …
[HTML][HTML] Sex differences of microglia in the healthy brain from embryonic development to adulthood and across lifestyle influences
BC Bobotis, O Braniff, M Gargus, ET Akinluyi… - Brain research …, 2023 - Elsevier
Microglia, the central nervous system innate immune cells, play a critical role in maintaining
a homeostatic environment in the brain throughout life. These cells exhibit an impressive …
a homeostatic environment in the brain throughout life. These cells exhibit an impressive …
Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress
SC Woodburn, HS Asrat, JK Flurer… - Brain, behavior, and …, 2023 - Elsevier
In the medial prefrontal cortex (PFC), chronic stress reduces synaptic expression of
glutamate receptors, leading to decreased excitatory signaling from layer V pyramidal …
glutamate receptors, leading to decreased excitatory signaling from layer V pyramidal …