Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Executioner caspases, when activated, cleave hundreds or thousands of substrates in the
cell to orchestrate apoptosis. In most animals, the executioner caspases have short …

Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine
maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major …

Inflammasome complexes function as key innate immune effectors that trigger inflammation
in response to pathogen-and danger-associated signals. Here, we report that germline …

Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen
overdose is the number one cause of acute liver failure and remains a major problem in …

The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …

Caspases not only play an essential role during apoptotic cell death, but a subfamily of them—
the inflammatory caspases—are associated with immune responses to microbial pathogens …

The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death
effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and …

The intraerythrocytic parasite Plasmodium—the causative agent of malaria—produces an
inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is …

The innate immune system and inflammatory response in the brain have critical impacts on
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …