Photocatalysis in the life science industry
L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …
industry require access to mild and robust synthetic methodologies to systematically modify …
Spirocyclic scaffolds in medicinal chemistry
Spirocyclic scaffolds are incorporated in various approved drugs and drug candidates. The
increasing interest in less planar bioactive compounds has given rise to the development of …
increasing interest in less planar bioactive compounds has given rise to the development of …
Visible light-driven radical-mediated C–C bond cleavage/functionalization in organic synthesis
XY Yu, JR Chen, WJ ** into three-dimensional chemical space through a quaternary carbon
TT Talele - Journal of Medicinal Chemistry, 2020 - ACS Publications
A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …
Gold-catalyzed synthesis of small rings
Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …
fascinated chemists ever since their discovery. However, due to energetic considerations …
Enantio‐and Diastereodivergent Synthesis of Spirocycles through Dual‐Metal‐Catalyzed [3+ 2] Annulation of 2‐Vinyloxiranes with Nucleophilic Dipoles
Y Peng, X Huo, Y Luo, L Wu, W Zhang - Angewandte Chemie, 2021 - Wiley Online Library
The development of efficient and straightforward methods for obtaining all optically active
isomers of structurally rigid spirocycles from readily available starting materials is of great …
isomers of structurally rigid spirocycles from readily available starting materials is of great …
New development in the enantioselective synthesis of spiro compounds
A Ding, M Meazza, H Guo, JW Yang… - Chemical Society Reviews, 2018 - pubs.rsc.org
The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …
Despite their unique 3D properties and presence in several natural products, the difficulty in …
Transition-metal-catalyzed functionalization of alkynes with organoboron reagents: new trends, mechanistic insights, and applications
J Corpas, P Mauleon, RG Arrayás, JC Carretero - ACS Catalysis, 2021 - ACS Publications
Catalytic functionalization of alkynes with organoboron reagents provides a straightforward
access to stereochemically defined multisubstituted alkenes, which are structural motifs …
access to stereochemically defined multisubstituted alkenes, which are structural motifs …