Advances in computational modelling for personalised medicine after myocardial infarction

K Mangion, H Gao, D Husmeier, X Luo, C Berry - Heart, 2018 - heart.bmj.com
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide.
Determining which patients will experience heart failure and sudden cardiac death after an …

Image-based predictive modeling of heart mechanics

VY Wang, PMF Nielsen, MP Nash - Annual review of biomedical …, 2015 - annualreviews.org
Personalized biophysical modeling of the heart is a useful approach for noninvasively
analyzing and predicting in vivo cardiac mechanics. Three main developments support this …

Parameter estimation in a Holzapfel–Ogden law for healthy myocardium

H Gao, WG Li, L Cai, C Berry, XY Luo - Journal of engineering …, 2015 - Springer
A central problem in biomechanical studies of personalized human left ventricular (LV)
modelling is to estimate material properties from in vivo clinical measurements. In this work …

Physics-informed neural network estimation of material properties in soft tissue nonlinear biomechanical models

F Caforio, F Regazzoni, S Pagani, E Karabelas… - Computational …, 2024 - Springer
The development of biophysical models for clinical applications is rapidly advancing in the
research community, thanks to their predictive nature and their ability to assist the …

[HTML][HTML] Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference …

L Marx, JA Niestrawska, MAF Gsell, F Caforio… - Journal of computational …, 2022 - Elsevier
Image-based computational models of the heart represent a powerful tool to shed new light
on the mechanisms underlying physiological and pathological conditions in cardiac function …

Changes and classification in myocardial contractile function in the left ventricle following acute myocardial infarction

H Gao, A Aderhold, K Mangion… - Journal of The …, 2017 - royalsocietypublishing.org
In this research, we hypothesized that novel biomechanical parameters are discriminative in
patients following acute ST-segment elevation myocardial infarction (STEMI). To identify …

In vivo estimation of passive biomechanical properties of human myocardium

A Palit, SK Bhudia, TN Arvanitis, GA Turley… - Medical & biological …, 2018 - Springer
Identification of in vivo passive biomechanical properties of healthy human myocardium from
regular clinical data is essential for subject-specific modelling of left ventricle (LV). In this …

Dynamic finite-strain modelling of the human left ventricle in health and disease using an immersed boundary-finite element method

H Gao, D Carrick, C Berry, BE Griffith… - IMA journal of applied …, 2014 - ieeexplore.ieee.org
Detailed models of the biomechanics of the heart are important both for develo**
improved interventions for patients with heart disease and also for patient risk stratification …

Improved identifiability of myocardial material parameters by an energy-based cost function

A Nasopoulou, A Shetty, J Lee, D Nordsletten… - … and modeling in …, 2017 - Springer
Myocardial stiffness is a valuable clinical biomarker for the monitoring and stratification of
heart failure (HF). Cardiac finite element models provide a biomechanical framework for the …

Characterizing variability in passive myocardial stiffness in healthy human left ventricles using personalized MRI and finite element modeling

FO Kolawole, VY Wang, B Freytag, M Loecher… - Scientific Reports, 2025 - nature.com
Abnormal passive stiffness of the heart muscle (myocardium) is evident in the
pathophysiology of several cardiovascular diseases, making it an important indicator of …