Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

PRIMPOL repriming allows DNA replication to skip DNA lesions, leading to ssDNA gaps.
These gaps must be filled to preserve genome stability. Using a DNA fiber approach to …

Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA
replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress …

Mutation signatures associated with apolipoprotein B mRNA editing catalytic polypeptide-
like 3A/B (APOBEC3A/B) cytidine deaminases are prevalent across cancers, implying their …

Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are
considered to form through homologous recombination (HR). Indeed, SCE induction upon …

PARP inhibitors (PARPi), known for their ability to induce replication gaps and accelerate
replication forks, have become potent agents in anticancer therapy. However, the molecular …

Members of the primase-polymerase (Prim-Pol) superfamily are found in all domains of life
and play diverse roles in genome stability, including primer synthesis during DNA …

Recent studies have described a DNA damage tolerance pathway choice that involves a
competition between PrimPol-mediated repriming and fork reversal. Screening different …

Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA
repair by removal of poly (ADP-ribose)(PAR) from PARylated proteins. Loss or inhibition of …