Metabolic engineering can have a pivotal role in increasing the environmental sustainability
of the transportation and chemical manufacturing sectors. The field has already developed …

Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

High titer, rate, yield (TRY), and scalability are challenging metrics to achieve due to trade-
offs between carbon use for growth and production. To achieve these metrics, we take the …

Research studies on NAD+ have proven its crucial role in aging and disease. Nicotinamide
mononucleotide (NMN), as the key intermediate of NAD+, plays a significant role in …

The emergence of photosynthetic biohybrid systems provides an environmentally friendly
and sustainable approach to produce fuels and chemicals in microbial cell factories …

Metabolic engineering often entails concurrent engineering of substrate utilization, central
metabolism and product synthesis pathways, inevitably creating interdependency with …

Rising demands for enzymes in biotechnological applications have fueled efforts to tailor
their properties towards desired functions, such as activity, selectivity, and stability …

Microbial communication can drive coordinated functions through sensing, analyzing and
processing signal information, playing critical roles in biomanufacturing and life evolution …

Cost competitive conversion of biomass-derived sugars into biofuel will require high yields,
high volumetric productivities and high titers. Suitable production parameters are hard to …

Noncanonical redox cofactors are attractive low-cost alternatives to nicotinamide adenine
dinucleotide (phosphate)(NAD (P)+) in biotransformation. However, engineering enzymes to …