Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
The increasing prevalence of poorly soluble drugs in development provides notable risk of
new products demonstrating low and erratic bioavailabilty with consequences for safety and …
new products demonstrating low and erratic bioavailabilty with consequences for safety and …
Recent advances in crystal engineering
The articles published in the tenth anniversary issue of CrystEngComm are reviewed. The
issue highlighted the state-of-the-art of crystal engineering and new trends and develo** …
issue highlighted the state-of-the-art of crystal engineering and new trends and develo** …
Building co-crystals with molecular sense and supramolecular sensibility
CB Aakeröy, DJ Salmon - CrystEngComm, 2005 - pubs.rsc.org
Molecular recognition is typically associated with molecules in solution, but such events are
also responsible for organizing molecules in the solid state. Translating principles of …
also responsible for organizing molecules in the solid state. Translating principles of …
Synthesis and structural characterization of cocrystals and pharmaceutical cocrystals: mechanochemistry vs slow evaporation from solution
DR Weyna, T Shattock, P Vishweshwar… - Crystal Growth and …, 2009 - ACS Publications
The reliability of solvent drop grinding (SDG), also referred to as liquid assisted grinding, wet
cogrinding, or mechanochemistry, to facilitate cocrystal formation is addressed with a series …
cogrinding, or mechanochemistry, to facilitate cocrystal formation is addressed with a series …
Mechanochemistry and co-crystal formation: effect of solvent on reaction kinetics
N Shan, F Toda, W Jones - Chemical Communications, 2002 - pubs.rsc.org
Mechanochemistry and co-crystal formation: effect of solvent on reaction kinetics - Chemical
Communications (RSC Publishing) DOI:10.1039/B207369M Royal Society of Chemistry …
Communications (RSC Publishing) DOI:10.1039/B207369M Royal Society of Chemistry …
Tape and layer structures in cocrystals of some di-and tricarboxylic acids with 4, 4′-bipyridines and isonicotinamide. From binary to ternary cocrystals
Linear, zigzag tapes and flat, corrugated sheet structures are described in binary cocrystals
1–9 of some di-and tricarboxylic acids with 4, 4′-bipyridine bases and isonicotinamide …
1–9 of some di-and tricarboxylic acids with 4, 4′-bipyridine bases and isonicotinamide …
Cocrystals for photochemical solid-state reactions: An account on crystal engineering perspective
Syntheses of functional cyclobutanes, ie, strained four-membered ring compounds are
mainly achieved via photochemical [2+ 2] cycloaddition reaction. The key is to bring two …
mainly achieved via photochemical [2+ 2] cycloaddition reaction. The key is to bring two …
Screening for pharmaceutical cocrystal hydrates via neat and liquid-assisted grinding
S Karki, T Friščić, W Jones… - Molecular …, 2007 - ACS Publications
The formation of cocrystal hydrates represents a potential route to achieve molecular
materials with improved properties, particularly stability under conditions of high relative …
materials with improved properties, particularly stability under conditions of high relative …
Crystal engineering of organic cocrystals by the solid-state grinding approach
AV Trask, W Jones - Organic Solid State Reactions: -/-, 2005 - Springer
Crystal engineering of organic cocrystals is gaining interest across a variety of disciplines.
The solid-state grinding approach to preparing cocrystals is an alternative to the traditional …
The solid-state grinding approach to preparing cocrystals is an alternative to the traditional …
Crystal engineering of the composition of pharmaceutical phases
RDB Walsh, MW Bradner, S Fleischman… - Chemical …, 2003 - pubs.rsc.org
Crystal engineering of the composition of pharmaceutical phases - Chemical Communications
(RSC Publishing) DOI:10.1039/B208574G Royal Society of Chemistry View PDF …
(RSC Publishing) DOI:10.1039/B208574G Royal Society of Chemistry View PDF …