Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis
C Mohan, C Putterman - Nature Reviews Nephrology, 2015 - nature.com
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …
Murine models of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele.
Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X …
Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X …
Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis
S Bolland, JV Ravetch - Immunity, 2000 - cell.com
By virtue of its ability to couple the BCR to an inhibitory pathway, FcγRIIB can potentially
determine the fate of B cells upon IgG immune complex engagement. We now provide …
determine the fate of B cells upon IgG immune complex engagement. We now provide …
Amyloid-DNA composites of bacterial biofilms stimulate autoimmunity
Research on the human microbiome has established that commensal and pathogenic
bacteria can influence obesity, cancer, and autoimmunity through mechanisms mostly …
bacteria can influence obesity, cancer, and autoimmunity through mechanisms mostly …
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
L Morel, BP Croker, KR Blenman… - Proceedings of the …, 2000 - National Acad Sciences
We previously produced three congenic strains carrying lupus susceptibility genes (Sle1-
Sle3) from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized …
Sle3) from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized …
Delineating the genetic basis of systemic lupus erythematosus
Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus
(SLE) in both human patients and animal models. Recent progress in experimental systems …
(SLE) in both human patients and animal models. Recent progress in experimental systems …
TLR7 and TLR9 in SLE: when sensing self goes wrong
T Celhar, R Magalhaes, AM Fairhurst - Immunologic research, 2012 - Springer
Autoreactive B and T cells are present in healthy, autoimmunity-free individuals, but they are
kept in check by various regulatory mechanisms. In systemic lupus erythematosus (SLE) …
kept in check by various regulatory mechanisms. In systemic lupus erythematosus (SLE) …
Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
RJ Cornall, JG Cyster, ML Hibbs, AR Dunn, KL Otipoby… - Immunity, 1998 - cell.com
AB lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus
characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell …
characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell …
The genetics of complex autoimmune diseases: non-MHC susceptibility genes
A Wanstrat, E Wakeland - Nature immunology, 2001 - nature.com
Susceptibility to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by
a variety of genetic and environmental or stochastic factors. After over a decade of linkage …
a variety of genetic and environmental or stochastic factors. After over a decade of linkage …