Ocular drug delivery: a comprehensive review

S Ahmed, MM Amin, S Sayed - AAPS PharmSciTech, 2023 - Springer
The human eye is a sophisticated organ with distinctive anatomy and physiology that
hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration …

Chitosan and its derivatives for ocular delivery formulations: Recent advances and developments

A Zamboulis, S Nanaki, G Michailidou, I Koumentakou… - Polymers, 2020 - mdpi.com
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Nanosuspensions in ophthalmology: Overcoming challenges and enhancing drug delivery for eye diseases

S Fathi-Karkan, NA Ramsheh, H Arkaban… - International Journal of …, 2024 - Elsevier
This review article provides a comprehensive overview of the advancements in using
nanosuspensions for controlled drug delivery in ophthalmology. It highlights the significance …

Nano-based drug delivery system: recent strategies for the treatment of ocular disease and future perspective

Z Qamar, FF Qizilbash, MK Iqubal, A Ali… - Recent Patents on …, 2019 - ingentaconnect.com
The structure of the eye is very complex in nature which makes it a challenging task for
pharmaceutical researchers to deliver the drug at the desired sites via different routes of …

Evaluation of antitumor efficacy of chitosan-tamarind gum polysaccharide polyelectrolyte complex stabilized nanoparticles of simvastatin

R Malviya, S Raj, S Fuloria… - International journal …, 2021 - Taylor & Francis
Purpose The present study was intended to fabricate chitosan (Ch)-tamarind gum
polysaccharide (TGP) polyelectrolyte complex stabilized cubic nanoparticles of simvastatin …

[HTML][HTML] A review on the modification of polysaccharide through graft copolymerization for various potential applications

D Kumar, J Pandey, V Raj, P Kumar - The open medicinal …, 2017 - ncbi.nlm.nih.gov
Results: Grafted polysaccharides have various applications in different important scientific
areas such as drug delivery, pharmaceutical field, plastic industry, waste water treatment …

Colloidal nanosystems with mucoadhesive properties designed for ocular topical delivery

B Silva, B São Braz, E Delgado, L Gonçalves - International Journal of …, 2021 - Elsevier
Over the last years, the scientific interest about topical ocular delivery targeting the posterior
segment of the eye has been increasing. This is probably due to the fact that this is a non …

Absorption enhancement strategies in chitosan-based nanosystems and hydrogels intended for ocular delivery: Latest advances for optimization of drug permeation

I Dmour - Carbohydrate Polymers, 2024 - Elsevier
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections,
etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes …

Ganciclovir nanosuspension-loaded detachable microneedles patch for enhanced drug delivery to posterior eye segment

P Suriyaamporn, C Pornpitchanarong… - Journal of Drug Delivery …, 2023 - Elsevier
Human cytomegalovirus (CMV) retinitis is a sight-threatening inflammation of the retina
commonly affected immunocompromised patients, eg, acquired immunodeficiency …

Challenges in the polyene-and azole-based pharmacotherapy of ocular fungal infections

P Lakhani, A Patil, S Majumdar - Journal of Ocular Pharmacology …, 2019 - liebertpub.com
Polyenes and azoles constitute 2 major drug classes in the antifungal armamentarium used
to treat fungal infections of the eye such as fungal keratitis, endophthalmitis, conjunctivitis …