Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease worldwide.
Chronic hyperglycemia and high blood pressure are the main risk factors for the …

Management of diabetic kidney disease (DKD) has evolved in parallel with our growing
understanding of the multiple interrelated pathophysiological mechanisms that involve …

In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

Background Systemic immune-inflammation index (SII) is a novel inflammatory marker, and
inflammation has been reported to be related with renal damage. We aimed to investigate …

Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Although chronic kidney disease is characterized by low glomerular filtration rate (GFR) or
albuminuria, estimated GFR (eGFR) is more widely utilized as a marker of risk profile in …

There is currently an unmet need for effective treatment of chronic kidney disease (CKD) that
slows disease progression, prevents development of end-stage kidney disease and …

Importance Steroidal mineralocorticoid receptor antagonists, when added to a renin-
angiotensin system blocker, further reduce proteinuria in patients with chronic kidney …

Chronic kidney disease (CKD) affects a 15% of Americans, and diabetic kidney disease
(DKD) is the most common cause of kidney failure. 1, 2 Although the incidence of diabetes …

Aims To compare the occurrence of cerebral, cardiovascular, and renal events in patients
with hyperuricaemia treated with febuxostat and those treated with conventional therapy with …