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Gold complexes in anticancer therapy: from new design principles to particle‐based delivery systems
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …
synthesis of new anticancer metallodrugs, which have received special attention due to their …
Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases
Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …
are well established in the clinical application of cancer chemotherapy. However, the …
[HTML][HTML] Interactions of nanoparticles and biosystems: microenvironment of nanoparticles and biomolecules in nanomedicine
C Auría-Soro, T Nesma, P Juanes-Velasco… - Nanomaterials, 2019 - mdpi.com
Nanotechnology is a multidisciplinary science covering matters involving the nanoscale
level that is being developed for a great variety of applications. Nanomedicine is one of …
level that is being developed for a great variety of applications. Nanomedicine is one of …
The gold complex auranofin: new perspectives for cancer therapy
FH Abdalbari, CM Telleria - Discover oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …
to the lack of long-term treatment options following the standard form of care. New options …
Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness
T Gamberi, G Chiappetta, T Fiaschi… - Medicinal Research …, 2022 - Wiley Online Library
Auranofin is an oral gold (I) compound, initially developed for the treatment of rheumatoid
arthritis. Currently, Auranofin is under investigation for oncological application within a drug …
arthritis. Currently, Auranofin is under investigation for oncological application within a drug …
Biological applications of thiocarbohydrazones and their metal complexes: A perspective review
C Bonaccorso, T Marzo, D La Mendola - Pharmaceuticals, 2019 - mdpi.com
Although organic compounds account for more than 99% of currently approved clinical
drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis …
drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis …
[HTML][HTML] Strategies for the improvement of metal-based chemotherapeutic treatments
This article provides an overview of the various research approaches we have explored in
recent years to improve metal-based agents for cancer or infection treatments. Although …
recent years to improve metal-based agents for cancer or infection treatments. Although …
Advances in alkynyl gold complexes for use as potential anticancer agents
Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …
chemists due to their unique chemical properties and strong antiproliferative potency …
ESI MS studies highlight the selective interaction of Auranofin with protein free thiols
The clinically established gold drug Auranofin was reacted individually with a group of
representative proteins, namely ubiquitin, ribonuclease A, carbonic anhydrase …
representative proteins, namely ubiquitin, ribonuclease A, carbonic anhydrase …
[HTML][HTML] Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cells
FH Abdalbari, E Martinez-Jaramillo, BN Forgie, E Tran… - Cancers, 2023 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) is the most prevalent type of
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …