Gold complexes in anticancer therapy: from new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases

Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

[HTML][HTML] Interactions of nanoparticles and biosystems: microenvironment of nanoparticles and biomolecules in nanomedicine

C Auría-Soro, T Nesma, P Juanes-Velasco… - Nanomaterials, 2019 - mdpi.com
Nanotechnology is a multidisciplinary science covering matters involving the nanoscale
level that is being developed for a great variety of applications. Nanomedicine is one of …

The gold complex auranofin: new perspectives for cancer therapy

FH Abdalbari, CM Telleria - Discover oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness

T Gamberi, G Chiappetta, T Fiaschi… - Medicinal Research …, 2022 - Wiley Online Library
Auranofin is an oral gold (I) compound, initially developed for the treatment of rheumatoid
arthritis. Currently, Auranofin is under investigation for oncological application within a drug …

Biological applications of thiocarbohydrazones and their metal complexes: A perspective review

C Bonaccorso, T Marzo, D La Mendola - Pharmaceuticals, 2019 - mdpi.com
Although organic compounds account for more than 99% of currently approved clinical
drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis …

[HTML][HTML] Strategies for the improvement of metal-based chemotherapeutic treatments

D Cirri, F Bartoli, A Pratesi, E Baglini, E Barresi… - Biomedicines, 2021 - mdpi.com
This article provides an overview of the various research approaches we have explored in
recent years to improve metal-based agents for cancer or infection treatments. Although …

Advances in alkynyl gold complexes for use as potential anticancer agents

Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …

ESI MS studies highlight the selective interaction of Auranofin with protein free thiols

C Zoppi, L Messori, A Pratesi - Dalton Transactions, 2020 - pubs.rsc.org
The clinically established gold drug Auranofin was reacted individually with a group of
representative proteins, namely ubiquitin, ribonuclease A, carbonic anhydrase …

[HTML][HTML] Auranofin induces lethality driven by reactive oxygen species in high-grade serous ovarian cancer cells

FH Abdalbari, E Martinez-Jaramillo, BN Forgie, E Tran… - Cancers, 2023 - mdpi.com
Simple Summary High-grade serous ovarian cancer (HGSOC) is the most prevalent type of
ovarian cancer, accounting for 70% of ovarian cancer deaths. This is primarily due to the …