Multivalent glycosystems for human lectins

M Martínez-Bailén, J Rojo… - Chemical Society …, 2023 - pubs.rsc.org
Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

Glycans in drug discovery

P Valverde, A Ardá, NC Reichardt… - …, 2019 - pubs.rsc.org
Glycans are key players in many biological processes. They are essential for protein folding
and stability and act as recognition elements in cell–cell and cell–matrix interactions. Thus …

Glycan-gold nanoparticles as multifunctional probes for multivalent lectin–carbohydrate binding: implications for blocking virus infection and nanoparticle assembly

D Budhadev, E Poole, I Nehlmeier, Y Liu… - Journal of the …, 2020 - ACS Publications
Multivalent lectin-glycan interactions are widespread in biology and are often exploited by
pathogens to bind and infect host cells. Glycoconjugates can block such interactions and …

[HTML][HTML] Glycan structures and their interactions with proteins. A NMR view

A Gimeno, P Valverde, A Ardá… - Current opinion in …, 2020 - Elsevier
Highlights•NMR methods are of paramount importance to deduce structure, dynamics and
recognition of complex glycans.•The intrinsic low sensitivity of NMR for studying glycans and …

Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets

MM Sauer, RP Jakob, T Luber… - Journal of the …, 2018 - ACS Publications
Multivalent carbohydrate–lectin interactions at host–pathogen interfaces play a crucial role
in the establishment of infections. Although competitive antagonists that prevent pathogen …

Recent progress of glycopolymer synthesis for biomedical applications

I Pramudya, H Chung - Biomaterials science, 2019 - pubs.rsc.org
Glycopolymers are an important class of biomaterials which include carbohydrate moieties
in their polymer structure. In addition to biological research on the interactions of …

The rise and future of discrete organic–inorganic hybrid nanomaterials

MW Brett, CK Gordon, J Hardy… - ACS Physical Chemistry …, 2022 - ACS Publications
Hybrid nanomaterials (HNs), the combination of organic semiconductor ligands attached to
nanocrystal semiconductor quantum dots, have applications that span a range of practical …

Recent advances in nanoparticle-based targeting tactics for antibacterial photodynamic therapy

BA Thomas-Moore, CA Del Valle, RA Field… - Photochemical & …, 2022 - Springer
The rise of antibacterial drug resistance means treatment options are becoming increasingly
limited. We must find ways to tackle these hard-to-treat drug-resistant and biofilm infections …

Structure–effect relationship studies of polysaccharides based on receptor–active centres: an alternative view

W Zhang, X Zhang, Q Bai, L Liang, S Wang, L Guo - Food & Function, 2023 - pubs.rsc.org
Polysaccharides are ubiquitous biomolecules found in nature that have attracted research
interest due to their unique nutritional and pharmacological value. Their structural variability …

Polyvalent Glycan Quantum Dots as a Multifunctional Tool for Revealing Thermodynamic, Kinetic, and Structural Details of Multivalent Lectin–Glycan Interactions

J Hooper, Y Liu, D Budhadev, DF Ainaga… - … applied materials & …, 2022 - ACS Publications
Multivalent lectin–glycan interactions (MLGIs) are widespread and vital for biology. Their
binding biophysical and structural details are thus highly valuable, not only for the …