IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies

A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

Maternal-fetal inflammation in the placenta and the developmental origins of health and disease

JA Goldstein, K Gallagher, C Beck, R Kumar… - Frontiers in …, 2020 - frontiersin.org
Events in fetal life impact long-term health outcomes. The placenta is the first organ to form
and is the site of juxtaposition between the maternal and fetal circulations. Most diseases of …

Placental pathology in COVID-19

ED Shanes, LB Mithal, S Otero, HA Azad… - American journal of …, 2020 - academic.oup.com
Objectives To describe histopathologic findings in the placentas of women with coronavirus
disease 2019 (COVID-19) during pregnancy. Methods Pregnant women with COVID-19 …

Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics

KR Theis, R Romero, AD Winters, JM Greenberg… - American journal of …, 2019 - Elsevier
Background The human placenta has been traditionally viewed as sterile, and microbial
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

V Garcia-Flores, R Romero, Y Xu, KR Theis… - Nature …, 2022 - nature.com
Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality.
However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and …

The impact of COVID-19 on pregnancy outcomes in a diverse cohort in England

M Wilkinson, ED Johnstone, LE Simcox, JE Myers - Scientific reports, 2022 - nature.com
There is conflicting evidence regarding the effect of coronavirus disease (COVID-19) in
pregnancy. Risk factors for COVID-19 overlap with risk factors for pregnancy complications …

[HTML][HTML] Evidence that intra-amniotic infections are often the result of an ascending invasion–a molecular microbiological study

R Romero, N Gomez-Lopez, AD Winters… - Journal of perinatal …, 2019 - degruyter.com
Background Microbial invasion of the amniotic cavity resulting in intra-amniotic infection is
associated with obstetrical complications such as preterm labor with intact or ruptured …

Chronic inflammatory placental disorders associated with recurrent adverse pregnancy outcome

EF Cornish, T McDonnell, DJ Williams - Frontiers in Immunology, 2022 - frontiersin.org
Chronic inflammatory placental disorders are a group of rare but devastating gestational
syndromes associated with adverse pregnancy outcome. This review focuses on three …

[HTML][HTML] Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified …

R Romero, E Jung, T Chaiworapongsa, O Erez… - American journal of …, 2022 - Elsevier
Background The major challenge for obstetrics is the prediction and prevention of the great
obstetrical syndromes. We propose that defining obstetrical diseases by the combination of …

The prediction of early preeclampsia: Results from a longitudinal proteomics study

AL Tarca, R Romero, N Benshalom-Tirosh, NG Than… - PloS one, 2019 - journals.plos.org
Objectives To identify maternal plasma protein markers for early preeclampsia (delivery< 34
weeks of gestation) and to determine whether the prediction performance is affected by …