Because of its profound effects on the rates of biological processes such as aerobic
metabolism, environmental temperature plays an important role in sha** the distribution …

The functions of many proteins are regulated through allostery, whereby effector binding at a
distal site changes the functional activity (eg, substrate binding affinity or catalytic efficiency) …

All soluble proteins populate conformational ensembles that together constitute the native
state. Their fluctuations in water are intrinsic thermodynamic phenomena, and the …

Allostery is largely associated with conformational and functional transitions in individual
proteins. This concept can be extended to consider the impact of conformational …

There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded,
Multi-Scale Machines Next Article in Journal Exploration of the Design of Spiderweb-Inspired …

Abstract Changes in protein conformation can affect protein function, but methods to probe
these structural changes on a global scale in cells have been lacking. To enable large-scale …

The seeding amplification assay (SAA) has recently emerged as a valuable tool for detecting
α-synuclein (αSyn) aggregates in various clinically accessible biospecimens. Despite its …

Orthologous proteins of species adapted to different temperatures exhibit differences in
stability and function that are interpreted to reflect adaptive variation in structural “flexibility.” …

Allostery is a biological phenomenon of fundamental importance in regulation and signaling,
and efforts to understand this process have led to the development of numerous models. In …

The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …