Two-dimensional spectroscopy is a powerful tool for extracting structural and dynamic
information from a wide range of chemical systems. We provide a brief overview of the ways …

Amyloid diseases, including neurodegenerative diseases such as Alzheimer's and
Parkinson's, are linked to a poorly understood progression of protein misfolding and …

COVID-19 is primarily known as a respiratory disease caused by SARS-CoV-2. However,
neurological symptoms such as memory loss, sensory confusion, severe headaches, and …

The aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of
Alzheimer's disease (AD) and related tauopathies. Disease-associated conformations of …

The neuropathology of Alzheimer's disease (AD) is characterized by hyperphosphorylated
tau neurofibrillary tangles (NFTs) and amyloid-beta (Aβ) plaques. Aβ plaques are …

UV light and other factors damage crystallin proteins in the eye lens, resulting in cataracts
that scatter light and affect vision. Little information exists about protein structures within …

The majority of 2D IR spectrometers operate at 1-10 kHz using Ti: Sapphire laser
technology. We report a 2D IR spectrometer designed around Yb: KGW laser technology …

Abstract The cosolvent 2, 2, 2‐trifluoroethanol (TFE) is often used to mimic protein
desiccation. We assessed the effects of TFE on cytosolic abundant heat soluble protein D …

Protein‐based pharmaceuticals are increasingly important, but their inherent instability
necessitates a “cold chain” requiring costly refrigeration during production, shipment, and …

Conspectus Infrared (IR) spectroscopy probes molecular structure at the level of the
chemical bond or functional group. In the case of proteins, the most informative band in the …