Recent progress of deubiquitinating enzymes in human and plant pathogenic fungi
W Wang, X Cai, XL Chen - Biomolecules, 2022 - mdpi.com
In eukaryotic cells, a large number of proteins are modified by ubiquitination, which leads to
proteasomal degradation or change in protein function. The protein ubiquitination process …
proteasomal degradation or change in protein function. The protein ubiquitination process …
Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial Candida glabrata isolates
Candida glabrata is one of the most common causes of systemic candidiasis, often resistant
to antifungal medications. To describe the genomic context of emerging resistance, we …
to antifungal medications. To describe the genomic context of emerging resistance, we …
Functional information from clinically-derived drug resistant forms of the Candida glabrata Pdr1 transcription factor
L Simonicova, WS Moye-Rowley - PLoS genetics, 2020 - journals.plos.org
Azole drugs are the most frequently used antifungal agents. The pathogenic yeast Candida
glabrata acquires resistance to azole drugs via single amino acid substitution mutations …
glabrata acquires resistance to azole drugs via single amino acid substitution mutations …
Evidence that ergosterol biosynthesis modulates activity of the Pdr1 transcription factor in Candida glabrata
BG Vu, GH Thomas, WS Moye-Rowley - MBio, 2019 - Am Soc Microbiol
ABSTRACT A crucial limitation in antifungal chemotherapy is the limited number of
antifungal drugs currently available. Azole drugs represent the most commonly used …
antifungal drugs currently available. Azole drugs represent the most commonly used …
Rapid, efficient auxin-inducible protein degradation in Candida pathogens
ABSTRACT A variety of inducible protein degradation (IPD) systems have been developed
as powerful tools for protein functional characterization. IPD systems provide a convenient …
as powerful tools for protein functional characterization. IPD systems provide a convenient …
Biochemical identification of a nuclear coactivator protein required for AtrR-dependent gene regulation in Aspergillus fumigatus
Azole drugs represent the primary means of treating infections associated with the
filamentous fungal pathogen Aspergillus fumigatus. A central player in azole resistance is …
filamentous fungal pathogen Aspergillus fumigatus. A central player in azole resistance is …
Two functionally redundant FK506-binding proteins regulate multidrug resistance gene expression and govern azole antifungal resistance
Increasing resistance to antifungal therapy is an impediment to the effective treatment of
fungal infections. Candida glabrata is an opportunistic human fungal pathogen that is …
fungal infections. Candida glabrata is an opportunistic human fungal pathogen that is …
Similarities and distinctions in the activation of the Candida glabrata Pdr1 regulatory pathway by azole and non-azole drugs
TP Conway, BG Vu, SR Beattie, DJ Krysan… - Msphere, 2024 - journals.asm.org
Incidences of fluconazole (FLC) resistance among Candida glabrata clinical isolates are a
growing issue in clinics. The pleiotropic drug response network in C. glabrata confers azole …
growing issue in clinics. The pleiotropic drug response network in C. glabrata confers azole …
Candida glabrata Hst1-Rfm1-Sum1 complex evolved to control virulence-related genes
N Vázquez-Franco, G Gutiérrez-Escobedo… - Fungal Genetics and …, 2022 - Elsevier
C. glabrata is an opportunistic fungal pathogen and the second most common cause of
opportunistic fungal infections in humans, that has evolved virulence factors to become a …
opportunistic fungal infections in humans, that has evolved virulence factors to become a …
Candida glabrata Hst1-Rfm1-Sum1 complex evolved to control virulence-related genes
E Orta Zavalza, N Vázquez-Franco… - Instituto de Ciencias …, 2022 - cathi.uacj.mx
C. glabrata is an opportunistic fungal pathogen and the second most common cause of
opportunistic fungal infections in humans, that has evolved virulence factors to become a …
opportunistic fungal infections in humans, that has evolved virulence factors to become a …