Ovarian damage from chemotherapy and current approaches to its protection
N Spears, F Lopes, A Stefansdottir… - Human reproduction …, 2019 - academic.oup.com
Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …
Chemotherapy-induced damage to ovary: mechanisms and clinical impact
Cancer is a major public health problem around the world. Currently, about 5% of women
diagnosed with cancer are of reproductive age. These young survivors may face …
diagnosed with cancer are of reproductive age. These young survivors may face …
Senescence and aging: the critical roles of p53
Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …
Cyclophosphamide triggers follicle activation and “burnout”; AS101 prevents follicle loss and preserves fertility
L Kalich-Philosoph, H Roness, A Carmely… - Science translational …, 2013 - science.org
Premature ovarian failure and infertility are major side effects of chemotherapy treatments in
young cancer patients. A more thorough understanding of the mechanism behind …
young cancer patients. A more thorough understanding of the mechanism behind …
Fertility preservation in women with cancer
M De Vos, J Smitz, TK Woodruff - The Lancet, 2014 - thelancet.com
Enhanced long-term survival rates of young women with cancer and advances in
reproductive medicine and cryobiology have culminated in an increased interest in fertility …
reproductive medicine and cryobiology have culminated in an increased interest in fertility …
Cellular responses to Cisplatin‐induced DNA damage
A Basu, S Krishnamurthy - Journal of nucleic acids, 2010 - Wiley Online Library
Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …
p53 family and cellular stress responses in cancer
J Pflaum, S Schlosser, M Müller - Frontiers in oncology, 2014 - frontiersin.org
p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …
How do chemotherapeutic agents damage the ovary?
BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …
increased risk of premature ovarian failure (POF) but the exact mechanism through which …
Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review
Doxorubicin (DOX)-induced toxicity and resistance are major obstacles in chemotherapeutic
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …
approaches. Despite effective in the treatment of numerous malignancies, some clinicians …
p63 and p73, the ancestors of p53
V Dötsch, F Bernassola… - Cold Spring …, 2010 - cshperspectives.cshlp.org
p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …