In chemical biology research, various fluorescent probes have been developed and used to
visualize target proteins or molecules in living cells and tissues, yet there are limitations to …

Raman microspectroscopy offers microbiologists a rapid and non-destructive technique to
assess the chemical composition of individual live microorganisms in near real time. In this …

BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

Lack of sensitive single-cell analysis tools has limited the characterization of metabolic
activity in cancer stem cells. By hyperspectral-stimulated Raman scattering imaging of single …

Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Raman spectroscopy is an increasingly popular technique in many areas, including biology
and medicine. It is based on Raman scattering, a phenomenon in which incident photons …

Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic
reprograming during therapeutic resistance development is under-studied. Here, through …

Chemical contrast has long been sought for label-free visualization of biomolecules and
materials in complex living systems. Although infrared spectroscopic imaging has come a …

Metabolic reprogramming in a subpopulation of cancer cells is a hallmark of tumor
chemoresistance. However, single-cell metabolic profiling is difficult because of the lack of a …

Mid-infrared (MIR) microscopy provides rich chemical and structural information about
biological samples, without staining. Conventionally, the long MIR wavelength severely …