Ependymal cilia: physiology and role in hydrocephalus

W Ji, Z Tang, Y Chen, C Wang, C Tan, J Liao… - Frontiers in Molecular …, 2022 - frontiersin.org
Cerebrospinal fluid (CSF), a colorless liquid that generally circulates from the lateral
ventricles to the third and fourth ventricles, provides essential nutrients for brain homeostasis …

[HTML][HTML] Mechanisms of cerebrospinal fluid and brain interstitial fluid production

J **ang, Y Hua, G **, RF Keep - Neurobiology of disease, 2023 - Elsevier
Fluid homeostasis is fundamental for brain function with cerebral edema and hydrocephalus
both being major neurological conditions. Fluid movement from blood into brain is one …

Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

TL Toft-Bertelsen, D Barbuskaite, EK Heerfordt… - Fluids and barriers of the …, 2022 - Springer
Background A range of neurological pathologies may lead to secondary hydrocephalus.
Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as …

Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

N MacAulay, RF Keep, T Zeuthen - Fluids and Barriers of the CNS, 2022 - Springer
Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is
continuously replenished by net fluid extraction from the vasculature by the secretory action …

Are standing osmotic gradients the main driver of cerebrospinal fluid production? A computational analysis

P Razzaghi Khamesi, V Charitatos… - Fluids and Barriers of …, 2023 - Springer
Background The mechanisms of cerebrospinal fluid (CSF) production by the ventricular
choroid plexus (ChP) have not been fully deciphered. One prominent hypothesized …

Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus

SD Lolansen, N Rostgaard, SN Andreassen… - Fluids and Barriers of …, 2021 - Springer
Background Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible
neurological condition of unresolved etiology characterized by a clinical triad of symptoms; …

TRPV4: Cell type-specific activation, regulation and function in the vertebrate eye

L Lapajne, CN Rudzitis, B Cullimore… - Current topics in …, 2022 - Elsevier
The architecture of the vertebrate eye is optimized for efficient delivery and transduction of
photons and processing of signaling cascades downstream from phototransduction. The …

Targeting choroid plexus epithelium as a novel therapeutic strategy for hydrocephalus

Y Yang, J He, Y Wang, C Wang, C Tan, J Liao… - Journal of …, 2022 - Springer
The choroid plexus is a tissue located in the lateral ventricles of the brain and is composed
mainly of choroid plexus epithelium cells. The main function is currently thought to be the …

Consideration of kinase inhibitors for the treatment of hydrocephalus

BL Blazer-Yost - International Journal of Molecular Sciences, 2023 - mdpi.com
Hydrocephalus is a devastating condition characterized by excess cerebrospinal fluid (CSF)
in the brain. Currently, the only effective treatment is surgical intervention, usually involving …

Following Ussing's legacy: From amphibian models to mammalian kidney and brain

BL Blazer-Yost - American Journal of Physiology-Cell …, 2022 - journals.physiology.org
Professor Hans H. Ussing (1911–2000) was one of the founding members of the field of
epithelial cell biology. He is most famous for the electrophysiological technique that he …