Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[HTML][HTML] Regulation of skeletal development and maintenance by Runx2 and Sp7
T Komori - International Journal of Molecular Sciences, 2024 - mdpi.com
Runx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial
transcription factors for bone development. The cotranscription factor Cbfb (core binding …
transcription factors for bone development. The cotranscription factor Cbfb (core binding …
Chondrocyte membrane–coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis
Osteoarthritis (OA) is a chronic joint disease characterized by progressive degeneration of
articular cartilage. A challenge in the development of disease-modifying drugs is effective …
articular cartilage. A challenge in the development of disease-modifying drugs is effective …
Integrin signalling in joint development, homeostasis and osteoarthritis
Integrins are key regulators of cell–matrix interactions during joint development and joint
tissue homeostasis, as well as in the development of osteoarthritis (OA). The signalling …
tissue homeostasis, as well as in the development of osteoarthritis (OA). The signalling …
[HTML][HTML] An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology
W Ni, H Zhang, Z Mei, Z Hongyi, Y Wu, W Xu, Y Ma… - Redox Biology, 2023 - Elsevier
Cartilage homeostasis is essential for chondrocytes to maintain proper phenotype and
metabolism. Because adult articular cartilage is avascular, chondrocytes must survive in low …
metabolism. Because adult articular cartilage is avascular, chondrocytes must survive in low …
Engineering the biomechanical microenvironment of chondrocytes towards articular cartilage tissue engineering
W Xu, J Zhu, J Hu, L **ao - Life Sciences, 2022 - Elsevier
Tissue engineering holds great promise in the generation of cartilage analogues for
cartilage injury repair and replacement. However, for a long time, a variety of issues have …
cartilage injury repair and replacement. However, for a long time, a variety of issues have …
A Ubiquitin‐Competitive Strategy Based on the Element Microenvironment to Treat Osteoarthritis
K Kong, Y Yang, Y Chang, Y Chen… - Advanced Functional …, 2024 - Wiley Online Library
Recent research on ferroptosis and cuproptosis has underscored the crucial role of trace
element regulation in osteoarthritis (OA) treatment. However, research systematically …
element regulation in osteoarthritis (OA) treatment. However, research systematically …