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Epigenetics as a mediator of plasticity in cancer
The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …
Epithelial-mesenchymal plasticity in cancer progression and metastasis
W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …
epithelial transition (MET), are fundamental processes in embryonic development and tissue …
Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment
LTH Phi, IN Sari, YG Yang, SH Lee, N Jun… - Stem cells …, 2018 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …
The key role of epigenetics in human disease prevention and mitigation
AP Feinberg - New England Journal of Medicine, 2018 - Mass Medical Soc
Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …
expression through alterations in DNA or associated factors (other than the DNA sequence) …
Methionine is a metabolic dependency of tumor-initiating cells
Understanding cellular metabolism holds immense potential for develo** new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
Molecular mechanisms of epithelial–mesenchymal transition
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …
New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis
L Sheng, S Zhuang - Frontiers in physiology, 2020 - frontiersin.org
Epithelial-mesenchymal transition (EMT) is described as the process in which injured renal
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …
tubular epithelial cells undergo a phenotype change, acquiring mesenchymal characteristics …
[HTML][HTML] Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family
Y Katsuno, R Derynck - Developmental cell, 2021 - cell.com
Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …