Targeting the mitotic machinery using anti-mitotic drugs for elimination of cancer cells is a
century-old concept, which continues to be routinely used as a first line of treatment in the …

Tumors of nearly every origin activate the expression of genes normally restricted to
gametogenic cells. These genes encode proteins termed cancer/testis (CT) antigens, since …

CEP55 was initially identified as a pivotal component of abscission, the final stage of
cytokinesis, serving to regulate the physical separation of two daughter cells. Over the past …

Cancer/testis antigens (CTAs) are a group of tumor antigens expressed in numerous cancer
tissues, as well as in the testis and placental tissues. There are over 200 CTAs supported by …

Cancer stem-like cells (CSCs) and tumor-initiating cells (TICs) are a small population of
cancer cells that share three properties: tumor initiating ability, self-renewal, and …

Cancer stem–like cells (CSC) are a small population of cancer cells with superior tumor
initiating, self-renewal, and differentiation properties. In this study, we show that the cancer …

The centrosomal protein, CEP 55, is a key regulator of cytokinesis, and its overexpression is
linked to genomic instability, a hallmark of cancer. However, the mechanism by which it …

Abstract Background The Cancer/Testis Antigens (CTAs) are an important group of proteins
that are typically restricted to the testis in the normal adult but are aberrantly expressed in …

Centrosome forms the backbone of cell cycle progression mechanism. Recent debates have
occurred regarding the essentiality of centrosome in cell cycle regulation. CEP family protein …

We recently showed that upregulation of a key oncogene FOXM1 precedes head and neck
squamous cell carcinoma (HNSCC) malignancy. Furthermore, we also identified a …