Advances in organ-on-a-chip engineering
Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editing
Abstract Chimeric Antigen Receptor (CAR) T-cells represent a breakthrough in personalized
cancer therapy. In this strategy, synthetic receptors comprised of antigen recognition …
cancer therapy. In this strategy, synthetic receptors comprised of antigen recognition …
Blastocyst-like structures generated from human pluripotent stem cells
Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA
Clinical application of induced pluripotent stem cells (iPSCs) is limited by the low efficiency
of iPSC derivation and the fact that most protocols modify the genome to effect cellular …
of iPSC derivation and the fact that most protocols modify the genome to effect cellular …
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Current neural induction protocols for human embryonic stem (hES) cells rely on embryoid
body formation, stromal feeder co-culture or selective survival conditions. Each strategy has …
body formation, stromal feeder co-culture or selective survival conditions. Each strategy has …
Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
Induced pluripotent stem cells in disease modelling and drug discovery
The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …
widespread enthusiasm for the development of new models of human disease, enhanced …
Growth factors, matrices, and forces combine and control stem cells
Stem cell fate is influenced by a number of factors and interactions that require robust control
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …
A decade of transcription factor-mediated reprogramming to pluripotency
K Takahashi, S Yamanaka - Nature reviews Molecular cell biology, 2016 - nature.com
The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
A platform for generation of chamber-specific cardiac tissues and disease modeling
Tissue engineering using cardiomyocytes derived from human pluripotent stem cells holds a
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …