Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse
neurodegenerative diseases. Current in vitro and in vivo approaches support that …

Uniparental inheritance of mitochondrial DNA (mtDNA) is an evolutionary trait found in
nearly all eukaryotes. In many species, including humans, the sperm mitochondria are …

Assisted reproductive technology (ART) refers to processing gametes in vitro and usually
involves in vitro fertilization. Originally developed for the treatment of infertility, culture of …

Objectives To gain insights into the technical feasibility of maternal spindle transfer (MST)
applied in the context of repeated in vitro fertilization (IVF) failures for the treatment of …

Simple Summary The mitochondrial genome is a multicopy circular DNA with high mutation
rates due to replication and repair errors. Mitochondrial DNA (mtDNA) heteroplasmy refers …

Maternal transmission of a wide spectrum of mutant alleles of mitochondrial DNA (mtDNA)
gives rise to metabolic diseases of differing penetrance, presentation, and prognosis to …

Two of the most promising techniques in terms of ex vivo skin imaging and quantifying are
confocal Raman microscopy and MALDI-TOF mass spectrometry imaging (MALDI-TOF MSI) …

Mitochondrial diseases require customized approaches for reproductive counseling,
addressing differences in recurrence risks and reproductive options. The majority of …

Mitochondrial DNA (mtDNA) mutations are often associated with incurable diseases and
lead to detectable pathogenic variants in 1 out of 200 babies. Uncoupling of the inheritance …

Purpose Providing additional insights on the efficacy of human nuclear transfer (NT). Here,
and earlier, NT has been applied to minimize transmission risk of mitochondrial DNA …