Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein
classes. PC is the only phospholipid which is currently known to be required for lipoprotein …

Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators
as a consequence of the interaction of the immune system with bacteria and bacterial wall …

Apolipoprotein (apo) E has roles beyond lipoprotein metabolism. The detrimental effects of
apoE4 in cardiovascular, neurological, and infectious diseases correlate with its structural …

Kupffer cells have been implicated in the pathogenesis of various liver diseases. However,
their involvement in metabolic disorders of the liver, including fatty liver disease, remains …

Hepatic steatosis is common in patients having severe hyperhomocysteinemia due to
deficiency for cystathionine β-synthase. However, the mechanism by which homocysteine …

Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of
remnant lipoproteins in the plasma and development of premature atherosclerosis. Although …

Background: Nonalcoholic fatty liver disease (NAFLD) is a continuous diseases spectrum
associated with obesity, type 2 diabetes, insulin resistance, and hyperlipidemia. Simple …

Atherosclerotic cardiovascular disease (CVD) is a collective term comprising of a group of
disorders of the heart and blood vessels. These diseases are the largest cause of morbidity …

Apolipoprotein B100 (apoB100) is expressed primarily in mammalian liver. It has 4536
amino acids, 25 cysteines (16 of which are in intramolecular disulfide bonds), and 20 N …

Background Studies in mice have shown that PPARα is an important regulator of hepatic
lipid metabolism and the acute phase response. However, little information is available on …