Gut-derived systemic inflammation as a driver of depression in chronic liver disease

VT Kronsten, TH Tranah, C Pariante… - Journal of hepatology, 2022 - Elsevier
Depression and chronic liver disease (CLD) are important causes of disability, morbidity and
mortality worldwide and their prevalence continues to rise. The rate of depression in CLD is …

Cognitive dysfunction in non-alcoholic fatty liver disease—current knowledge, mechanisms and perspectives

K Kjærgaard, ACD Mikkelsen, CW Wernberg… - Journal of Clinical …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the hepatic component of the
metabolic syndrome and now seemingly affects one-fourth of the world population. Features …

Prebiotic and probiotic modulation of the microbiota–gut–brain axis in depression

DE Radford-Smith, DC Anthony - Nutrients, 2023 - mdpi.com
Emerging evidence demonstrates that alterations to the gut microbiota can affect mood,
suggesting that the microbiota–gut–brain (MGB) axis contributes to the pathogenesis of …

Novel insights into non-alcoholic fatty liver disease and dementia: insulin resistance, hyperammonemia, gut dysbiosis, vascular impairment, and inflammation

SY Cheon, J Song - Cell & Bioscience, 2022 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by multiple
pathologies. The progression of dementia with NAFLD may be affected by various risk …

Is fatty liver associated with depression? A meta-analysis and systematic review on the prevalence, risk factors, and outcomes of depression and non-alcoholic fatty …

J **ao, LKE Lim, CH Ng, DJH Tan, WH Lim… - Frontiers in …, 2021 - frontiersin.org
Background and Aims: Both non-alcoholic fatty liver disease (NAFLD) and depression have
a high global prevalence which is projected to increase further. While studies exploring the …

Physical exercise prevented stress‐induced anxiety via improving brain RNA methylation

L Yan, J Wei, F Yang, M Wang, S Wang… - Advanced …, 2022 - Wiley Online Library
Physical exercise is effective in alleviating mental disorders by improving synaptic
transmission; however, the link between body endurance training and neural adaptation has …

Non-alcoholic fatty liver disease (NAFLD) and potential links to depression, anxiety, and chronic stress

S Shea, C Lionis, C Kite, L Atkinson, SS Chaggar… - Biomedicines, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease
worldwide, and is frequently linked to the metabolic syndrome. The latter represents a …

A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis

PN Newsome, AJ Sanyal, G Neff… - Nature …, 2023 - nature.com
Non-alcoholic steatohepatitis (NASH) is a progressive, inflammatory liver disease with no
approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled …

Association between nonalcoholic fatty liver disease and depression: A systematic review and meta-analysis of observational studies

Y Gu, W Zhang, Y Hu, Y Chen, J Shi - Journal of Affective Disorders, 2022 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) is associated with an increased
prevalence of psychological conditions such as depression and anxiety. However, the …

A narrative review of lifestyle management guidelines for metabolic dysfunction-associated steatotic liver disease

DI Wajcman, CJ Byrne, JF Dillon, PN Brennan… - Hepatology, 2024 - journals.lww.com
Conclusions: Most guidelines recommend weight reduction through physical activity and
improving nutrition, as these have proven positive effects on health outcomes when …