Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

A subset of glutamatergic synapses in the central nervous system contains zinc; it is
sequestered into the lumen of synaptic vesicles, where it colocalizes with glutamate …

This review covers a broad range of topics related to the actions of zinc on the cells of the
vertebrate retina. Much of this review relies on studies in which zinc was applied …

The retina transforms light entering the eye into a sophisticated neural representation of our
visual world. Specialized synapses, cells, and circuits in the retina have evolved to encode …

Horizontal cells (HCs) are inhibitory interneurons of the vertebrate retina. Unlike typical
neurons, HCs are chronically depolarized in the dark, leading to a constant influx of Ca2+ …

Zinc chloride (0.01 mM kept for 3h) is not toxic to cultured cerebellar granule neurons
(CGNs) while kainate (0.1 mM kept for 3h) demonstrates some but very low toxicity towards …

It was demonstrated in our recent study that Zn2+ had dual effects on Ca2+-permeable
AMPA receptors on carp retinal horizontal cells. However, the possible mechanism (s) …

Horizontal cells (HCs) are neurons of the outer retina, which provide inhibitory feedback
onto photoreceptors and contribute to image processing. HCs in teleosts are classified into …

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of
cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical …