Artificial intelligence in chemistry: current trends and future directions

ZJ Baum, X Yu, PY Ayala, Y Zhao… - Journal of Chemical …, 2021 - ACS Publications
The application of artificial intelligence (AI) to chemistry has grown tremendously in recent
years. In this Review, we studied the growth and distribution of AI-related chemistry …

Fundamentals and methods for T‐and B‐cell epitope prediction

JL Sanchez-Trincado… - Journal of …, 2017 - Wiley Online Library
Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
develo** pathogen‐specific memory that confers immunological protection. Memory and …

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

E Shrock, E Fujimura, T Kula, RT Timms, IH Lee… - Science, 2020 - science.org
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …

A sequence homology and bioinformatic approach can predict candidate targets for immune responses to SARS-CoV-2

A Grifoni, J Sidney, Y Zhang, RH Scheuermann… - Cell host & …, 2020 - cell.com
Effective countermeasures against the recent emergence and rapid expansion of the 2019
novel coronavirus (SARS-CoV-2) require the development of data and tools to understand …

In silico validation of the non‐antibiotic drugs acetaminophen and ibuprofen as antibacterial agents against red complex pathogens

J Vijayashree Priyadharsini - Journal of periodontology, 2019 - Wiley Online Library
Background Acetaminophen (APAP) and ibuprofen (IB) are drugs commonly used to
alleviate pain due to their anti‐inflammatory, anti‐pyretic, and analgesic effect. The aim of …

COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning

E Ong, MU Wong, A Huffman, Y He - Frontiers in immunology, 2020 - frontiersin.org
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective
and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 …

Therapeutics data commons: Machine learning datasets and tasks for drug discovery and development

K Huang, T Fu, W Gao, Y Zhao, Y Roohani… - arxiv preprint arxiv …, 2021 - arxiv.org
Therapeutics machine learning is an emerging field with incredible opportunities for
innovatiaon and impact. However, advancement in this field requires formulation of …

Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach

M Bhattacharya, AR Sharma, P Patra… - Journal of medical …, 2020 - Wiley Online Library
Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent
outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV …

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study

Z Yang, P Bogdan, S Nazarian - Scientific reports, 2021 - nature.com
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over
the world has led to over millions of deaths, and devastated the social, financial and political …

Immunoinformatics‐aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019‐nCoV

V Baruah, S Bose - Journal of medical virology, 2020 - Wiley Online Library
Abstract The 2019 novel coronavirus (2019‐nCoV) outbreak has caused a large number of
deaths with thousands of confirmed cases worldwide, especially in East Asia. This study …