Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

YK Tham, BC Bernardo, JYY Ooi, KL Weeks… - Archives of …, 2015 - Springer
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Nongenomic effects of thyroid hormones on the immune system cells: new targets, old players

P De Vito, V Balducci, S Leone, Z Percario, G Mangino… - Steroids, 2012 - Elsevier
It is now widely accepted that thyroid hormones, l-thyroxine (T4) and 3, 3′, 5-triiodo-l-
thyronine (T3), act as modulators of the immune response. Immune functions such as …

Thyroid hormone and recovery of cardiac function in patients with acute myocardial infarction: a strong association?

I Lymvaios, I Mourouzis, DV Cokkinos… - European Journal of …, 2011 - academic.oup.com
Objective This study investigated whether changes in thyroid hormone (TH) in plasma are
associated with the recovery of cardiac function in patients with acute myocardial infarction …

Effects of acute triiodothyronine treatment in patients with anterior myocardial infarction undergoing primary angioplasty: Evidence from a pilot randomized clinical trial …

CI Pantos, AG Trikas, EG Pissimisis, KP Grigoriou… - Thyroid, 2022 - liebertpub.com
Background: Thyroid hormone has a differential action on healthy and ischemic heart.
Triiodothyronine (T3) administration improved postischemic cardiac function while it limited …

Thyroid hormone signalling: from the dawn of life to the bedside

I Mourouzis, AM Lavecchia, C **naris - Journal of Molecular Evolution, 2020 - Springer
Thyroid hormone (TH) signalling is a key modulator of fundamental biological processes that
has been evolutionarily conserved in both vertebrate and invertebrate species. TH may have …

Cardioprotection and thyroid hormones

A **itore, G Nicolini, C Kusmic, G Iervasi… - Heart Failure …, 2016 - Springer
The evolution of cardiac disease after an acute ischemic event depends on a complex and
dynamic network of mechanisms alternating from ischemic damage due to acute coronary …

Cardioprotective effects of thyroid hormones in a rat model of myocardial infarction are associated with oxidative stress reduction

AL de Castro, AV Tavares, C Campos… - Molecular and cellular …, 2014 - Elsevier
Reactive oxygen species (ROS) are involved with progression from infarction to heart failure.
Studies show that thyroid hormones (TH) present cardioprotective effects. This study aims to …

Thyroid hormone improves the mechanical performance of the post-infarcted diabetic myocardium: a response associated with up-regulation of Akt/mTOR and AMPK …

I Mourouzis, I Giagourta, G Galanopoulos… - Metabolism, 2013 - Elsevier
Objective Thyroid hormone (TH) is shown to be protective against cardiac and pancreatic
injury. Thus, this study explored the potential effects of TH treatment on the functional status …

Dose-dependent effects of thyroid hormone on post-ischemic cardiac performance: potential involvement of Akt and ERK signalings

I Mourouzis, P Mantzouratou, G Galanopoulos… - Molecular and Cellular …, 2012 - Springer
The present study explored the effects of thyroid hormone (TH) treatment on post-ischemic
cardiac function and potential implicated mechanisms. Acute myocardial infarction (AMI) …

Thyroid hormone and heart failure: charting known pathways for cardiac repair/regeneration

P Mantzouratou, E Malaxianaki, D Cerullo… - Biomedicines, 2023 - mdpi.com
Heart failure affects more than 64 million people worldwide, having a serious impact on their
survival and quality of life. Exploring its pathophysiology and molecular bases is an urgent …