It is essential to acknowledge the efforts made thus far to manage or eliminate various
disease burden faced by humankind. However, the rising global trends of the so-called …

The wine industry produces thousands of tons of residues, which represent a waste
management issue, both ecologically and economically. The large amounts of grape by …

Chalcones are intermediate products in the biosynthesis of flavonoids, which possess a
wide range of biological properties, including antimicrobial and anticancer activities. The …

Flavonoids are a diversified group of natural substances which were discovered to provide a
variety of health benefits in human beings. Vegetables, fruits, wine and tea are the primary …

Alzheimer's disease is a neurodegenerative disorder that is the leading cause of dementia
in elderly patients. Amyloid-β peptide (1–42 oligomers) has been identified as a neurotoxic …

Chalcones, a class of secondary metabolites within the flavonoid family, are characterized
by a distinct C6-C3-C6 structure. They are prevalent in both edible and medicinal plants and …

Chalcones have a variety of cellular protective and regulatory functions that may have
therapeutic potential in many diseases. In addition, they are considered to affect key …

This work explores the study of a synthesized nickel complex as a possible inhibitor against
the main protease (Mpro) of the recent emerging coronavirus disease (COVID-19). Overall …

The passage of time that evoke aging; the tilted redox balance that contribute oxidative
entropy; the polarization of microglia cells that produce inflammatory phenotype; all …

Abstract We built the Curcumin Chalcone Derivatives Database (CCDD) to enable the
effective virtual screening of highly potent curcumin and its analogs. The two-dimensional …