As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

BACKGROUND The placenta is a unique and pivotal organ in reproduction, controlling
crucial growth and cell differentiation processes that ensure a successful pregnancy …

The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

A variety of adverse environmental factors during pregnancy cause maternal chronic stress.
Caffeine is a common stressor, and its consumption during pregnancy is widespread. Our …

Placenta-specific trophoblast and tumor cells exhibit many common characteristics.
Trophoblast cells invade maternal tissues while being tolerated by the maternal immune …

Metformin is a widely prescribed medication whose mechanism of action is not completely
defined and whose role in gestational diabetes management remains controversial. In …

The transport of drugs across the placenta is a point of great importance in pharmacotherapy
during pregnancy. However, the knowledge of drug transport in pregnancy is mostly based …

It is now well-established that microRNAs (miRNAs) are important regulators of gene
expression. The role of miRNAs in placental development and trophoblast function is …

The placenta is a temporary organ that plays critical roles at the maternal-fetal interface.
Normal development and function of the placenta is dependent on hormonal signaling …

Bisphenol A (BPA) is an endocrine disruptor extensively used in the production of
polycarbonate plastics and epoxy resins and a component of liquid and food containers. It is …