Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Retroviral DNA integration
The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …
Function of alternative splicing
Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
We studied human immunodeficiency virus, type 1 (HIV-1) integrase (IN) complexes derived
from nuclei of human cells stably expressing the viral protein from a synthetic gene. We …
from nuclei of human cells stably expressing the viral protein from a synthetic gene. We …
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …
enzymatic activities and chromosomal association. A novel genetic knockout model was …
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
We have reported that human immunodeficiency virus type 1 (HIV-1) integrase (IN) forms a
specific nuclear complex with human lens epithelium-derived growth factor/transcription co …
specific nuclear complex with human lens epithelium-derived growth factor/transcription co …
LEDGF (p75) promotes DNA-end resection and homologous recombination
Lens epithelium–derived growth factor p75 splice variant (LEDGF) is a chromatin-binding
protein known for its antiapoptotic activity and ability to direct human immunodeficiency virus …
protein known for its antiapoptotic activity and ability to direct human immunodeficiency virus …
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 …
Human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75)
protein was recently identified as a binding partner for HIV-1 integrase (IN) in human cells. In …
protein was recently identified as a binding partner for HIV-1 integrase (IN) in human cells. In …
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration …
Human immunodeficiency virus type 1 (HIV-1), feline immunodeficiency virus (FIV), and
Moloney murine leukemia virus (MoMLV) integrases were stably expressed to determine …
Moloney murine leukemia virus (MoMLV) integrases were stably expressed to determine …
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …
host cell factors have been implicated in its formation. In particular, recent results have …
Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1Replication
S Emiliani, A Mousnier, K Busschots, M Maroun… - Journal of Biological …, 2005 - jbc.org
The insertion of a DNA copy of its RNA genome into a chromosome of the hostcell is
mediated by the viral integrase with the help of mostlyuncharacterized cellular cofactors. We …
mediated by the viral integrase with the help of mostlyuncharacterized cellular cofactors. We …