Nutraceutical and health-promoting potential of lactoferrin, an iron-binding protein in human and animal: current knowledge

MF Ashraf, D Zubair, MN Bashir, M Alagawany… - … Trace Element Research, 2024‏ - Springer
Lactoferrin is a natural cationic iron-binding glycoprotein of the transferrin family found in
bovine milk and other exocrine secretions, including lacrimal fluid, saliva, and bile …

Biotherapy of experimental acute kidney injury: emerging novel therapeutic strategies

N Li, L Han, X Wang, O Qiao, L Zhang, Y Gong - Translational Research, 2023‏ - Elsevier
Acute kidney injury (AKI) is a complex and heterogeneous disease with high incidence and
mortality, posing a serious threat to human life and health. Usually, in clinical practice, AKI is …

Lactoferrin alleviates cyclophosphamide induced-nephropathy through suppressing the orchestration between Wnt4/β-catenin and ERK1/2/NF-κB signaling and …

OS Mohamed, NAA Baky, MM Sayed-Ahmed… - Life Sciences, 2023‏ - Elsevier
Aims Cyclophosphamide is an alkylating agent with vast arrays of therapeutic activity.
Currently, its medical use is limited due to its numerous adverse events, including …

Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced haemorrhagic cystitis via targeting Sphk1/S1P/MAPK, TLR-4/NF-κB, and NLRP3/caspase-1/IL-1β …

NAA Baky, AH Al-Najjar, HA Elariny, AS Sallam… - International …, 2022‏ - Elsevier
Background The use of cyclophosphamide (CP) as a chemotherapeutic agent is limited by
its major complication haemorrhagic cystitis (HC). Finding preventive, safe, and efficient …

Anti-ulcerogenic activity of Citrus medica var. sarcodactylis fruit extract nano-emulsion in gastric ulcer rat model through modulating HMBG1/TLR4/NF-κB and Nrf2 …

EAW El-Abd, SM Baraka, IAA Kassem… - Journal of Drug Delivery …, 2025‏ - Elsevier
One of the most prevalent gastrointestinal multi-etiological diseases is gastric ulcer, with
several consequences and serious side influences. Nowadays, nanotechnology is one of …

[HTML][HTML] Lactoferrin alleviates Western diet-induced cognitive impairment through the microbiome-gut-brain axis

Q He, LL Zhang, D Li, J Wu, YX Guo, J Fan… - Current Research in …, 2023‏ - Elsevier
Lactoferrin (Lf) has been shown to benefit cognitive function in several animal models. To
elucidate the underlying mechanisms, male C57BL/6J mice were randomly divided into the …

Manganese-Based Nanozyme Alleviates Acute Kidney Injury via Nrf2/HO-1 and PI3K/Akt/NF-κB Signaling Pathways

Y Zhang, H Wang, K Liu, R Sun, Y Wang… - ACS Biomaterials …, 2025‏ - ACS Publications
Acute renal injury (AKI) has a high incidence rate and mortality, but current treatment
methods are limited. As a kind of nanomaterial with enzyme-like activity, nanozyme has …

Lactoferrin alleviates gentamicin-induced acute kidney injury in rats by suppressing ferroptosis: Highlight on ACSL4, SLC7A11, NCOA4, FSP1 pathways and miR …

RM Salama, SF Darwish, R Yehia, AA Sallam… - Food and Chemical …, 2024‏ - Elsevier
The use of gentamicin (GNT) is associated with acute kidney injury (AKI). Ferroptosis is a
newly recognized iron-dependent, non-apoptotic cell death that can lead to AKI. Lactoferrin …

Efficacy of orally administered montmorillonite in myoglobinuric acute renal failure model in male rats

M Moshiri, A Roohbakhsh, A Shakeri… - Iranian Journal of …, 2023‏ - pmc.ncbi.nlm.nih.gov
Objective (s): Acute kidney injury can be associated with serious consequences and
therefore early treatment is critical to decreasing mortality and morbidity rate. We evaluated …

The Potential Renoprotective Effects of Ticagrelor in Rhabdomyolysis-Induced Acute Kidney Injury in Rat

ZT Hussein, AA Hussein - Maaen Journal for Medical …, 2024‏ - majms.alkafeel.edu.iq
Background: Rhabdomyolysis is a potentially lethal range of symptoms results from muscle
cell destruction. It is recognized by the escape of cell contents such as myoglobin, creatine …