Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease of
unknown etiology that mainly affects women in the childbearing age. SLE is a prototype type …

IL-7 plays many essential roles in human health and disease. Congenital deficiencies in IL-7
signaling result in profound immunodeficiency, polymorphisms in IL7Rα modulate …

The majority of patients with systemic lupus erythematosus (SLE) have high expression of
type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the …

Recent evidence suggests that systemic autoimmunity and immunodeficiency are not
separate entities, but rather are interconnected processes. Immunodeficiency results from …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
excessive production of a variety of autoantibodies, accumulation of immune complexes …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with abnormal T cell
immune responses. We hypothesized that aberrant expression of microRNAs (miRNAs) in T …

Microparticles (MPs) are vesicles derived from the plasma membrane of different cells, are
considered a source of circulating autoantigens, and can form immune complexes (MPs …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by a
profound immune dysregulation and the presence of a variety of autoantibodies. Aberrant …

B-cell abnormality including excessive activation and lymphopenia is a central feature of
systemic lupus erythematosus (SLE). Although activation threshold, auto-reaction and death …

Objective Lymphopenia is a frequent clinical manifestation and risk factor for infections in
SLE, but the underlying mechanisms are not fully understood. We previously identified novel …