Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations

AI Ritchie, JA Wedzicha - Clinics in chest medicine, 2020 - pmc.ncbi.nlm.nih.gov
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are episodes of
symptom worsening which have significant adverse consequences for patients …

Cellular and molecular mechanisms of chronic obstructive pulmonary disease

PJ Barnes - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease

L George, CE Brightling - Therapeutic advances in chronic …, 2016 - journals.sagepub.com
The chronic lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are
common affecting over 500 million people worldwide and causing substantial morbidity and …

Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers

M Bafadhel, S McKenna, S Terry, V Mistry… - American journal of …, 2011 - atsjournals.org
Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) are
heterogeneous with respect to inflammation and etiology. Objectives: Investigate biomarker …

Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD

ID Pavord, S Lettis, N Locantore, S Pascoe, PW Jones… - Thorax, 2016 - thorax.bmj.com
Objective We performed a review of studies of fluticasone propionate (FP)/salmeterol
(SAL)(combination inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA)) in patients …

Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial

M Bafadhel, S McKenna, S Terry, V Mistry… - American journal of …, 2012 - atsjournals.org
Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) and responses
to treatment are heterogeneous. Objectives: Investigate the usefulness of blood eosinophils …

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - publications.ersnet.org
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

COPD exacerbations: defining their cause and prevention

JA Wedzicha, TAR Seemungal - The lancet, 2007 - thelancet.com
Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of worsening
of symptoms, leading to substantial morbidity and mortality. COPD exacerbations are …

Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations

A Papi, CM Bellettato, F Braccioni… - American journal of …, 2006 - atsjournals.org
Rationale: Severe exacerbations of chronic obstructive pulmonary disease (COPD) are
major causes of health care costs mostly related to hospitalization. The role of infections in …

The pathology of chronic obstructive pulmonary disease

JC Hogg, W Timens - Annual Review of Pathology: Mechanisms …, 2009 - annualreviews.org
The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …