The thymus is the primary organ responsible for generating functional T cells in vertebrates.
Although T cell differentiation within the thymus has been an area of intense investigation …

In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and
medullary TECs and their subpopulations, have distinct roles in coordinating the …

T cell development in the thymus is essential for cellular immunity and depends on the
organotypic thymic epithelial microenvironment. In comparison with other organs, the size …

The distinguishing feature of adult stem cells is their extraordinary capacity to divide prior to
the onset of senescence. While stratified epithelia such as skin, prostate, and breast are …

Aging is associated with decreased immune function that leads to increased morbidity and
mortality in the elderly. Immune senescence is accompanied by age-related changes in two …

Aging is a continuous process that induces many alterations in the cytoarchitecture of
different organs and systems both in humans and animals. Moreover, it is associated with …

The generation of a peripheral T-cell pool is essential for normal immune system function.
CD4+ and CD8+ T cells are produced most efficiently in the thymus, which provides a …

The thymus is essential for the generation of self-tolerant effector and regulatory T cells.
Intrathymic T-cell development requires an intact stromal microenvironment, of which thymic …

Thymic involution is central to the decline in immune system function that occurs with age.
By regenerating the thymus, it may therefore be possible to improve the ability of the aged …

The epithelial architecture of the thymus fosters growth, differentiation, and T cell receptor
repertoire selection of large numbers of immature T cells that continuously feed the mature …